PROTAC Proteolysis Targeting Chimeric Molecules

Cat.No.	Name	Information
M40697	NX-5948	NX-5948 (BTK-IN-24) is an orally active, blood-brain barrier-penetrating, BTK-targeting degradation agent for the study of B-cell malignancies and autoimmune diseases. NX-5948 induces specific BTK protein degradation by the cereblon E3 ligase (CRBN) complex without degradation of other cereblon neo-substrates. NX-5948 mediates potent anti-inflammatory activity via BTK degradation with resultant inhibition of B cell activation.
M10423	DT2216	DT2216 is a BCL-XL protein hydrolysis targeting chimera (PROTAC) that ligates and degrades BCL-XL with E3 ubiquitin (E3) ligase. DT2216 is effective against a variety of BCL-XL-dependent leukemias and cancer cells.
M10793	BETd-260	BETd-260 (ZBC 260) is a PROTAC connected by the Cereblon ligand and bet ligands in leukemia cells RS4; 11 At low concentrations of 30 pM, BRD4 protein activity is reduced. BETd-260 significantly inhibits the activity of HCC cells in hepatocellular carcinoma and induces apoptosis.