| Cat.No. | Name | Information |
|---|---|---|
| M40697 | NX-5948 | NX-5948 (BTK-IN-24) is an orally active, blood-brain barrier-penetrating, BTK-targeting degradation agent for the study of B-cell malignancies and autoimmune diseases. NX-5948 induces specific BTK protein degradation by the cereblon E3 ligase (CRBN) complex without degradation of other cereblon neo-substrates. NX-5948 mediates potent anti-inflammatory activity via BTK degradation with resultant inhibition of B cell activation. |
| M10423 | DT2216 | DT2216 is a BCL-XL protein hydrolysis targeting chimera (PROTAC) that ligates and degrades BCL-XL with E3 ubiquitin (E3) ligase. DT2216 is effective against a variety of BCL-XL-dependent leukemias and cancer cells. |
| M10382 | PROTAC SGK3 degrader-1 | PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a potent SGK3 degrader, it is a PROTAC conjugate of the 308-R SGK inhibitor with the VH032 VHL binding ligand, targeting SGK3. |
| M43435 | PROTAC BRD4 Degrader-17 | PROTAC BRD4 Degrader-17 is a potent PROTAC BRD4 Degrader, with IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)). |
| M43434 | PROTAC BRD4 Degrader-16 | PROTAC BRD4 Degrader-16 is a potent PROTAC BRD4 Degrader, with IC50 values of 34.58 nM (BRD4 (BD1)) and 40.23 nM (BRD4 (BD2)). |
| M43433 | PROTAC BRAF-V600E degrader-2 | PROTAC BRAF-V600E degrader-2 is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. |
| M43432 | SIAIS164018 hydrochloride | SIAIS164018 hydrochloride is a PROTAC-based ALK and EGFR degrader, with IC50 value of 2.5 nM and 6.6 nM for ALK and ALK G1202R, respectively. |
| M43431 | PROTAC Her3 Degrader-8 | PROTAC Her3 Degrader-8 is a PROTAC that can degrade Her3 protein in vitro and cell experiments, and can be used to study diseases regulated by HER family proteins. |
| M43430 | PROTAC CDK12/13 Degrader-1 TFA | PROTAC CDK12/13 Degrader-1 TFA is a highly selective cell cycle protein-dependent kinase CDK12/CDK13 dual degrader with the DC50 values of 2.2 nM and 2.1 nM, respectively. |
| M43429 | PROTAC α-synuclein degrader 5 | PROTAC α-synuclein degrader 5 is a highly selective small-molecule degraders (PROTAC) of α-synuclein aggregates, with an DC50 of 7.51 μM and the highest degradation rate Dmax of 89%. |
| M41912 | PROTAC KRAS G12C degrader-2 | PROTAC KRAS G12C degrader-2 is a modulator of K-Ras protein hydrolysis. |
| M41727 | JET-209 | JET-209 is a potent PROTAC CBP/p300 degrader, with DC50 values of 0.05 nM and 0.2 nM for CBP and p300. |
| M41387 | JH-XII-03-02 | JH-XII-03-02 is a potent and selective LRRK2 PROTAC degrader. |
| M40745 | PIK5-12d | PIK5-12d is a highly active and selective PIKfyve degrader constructed based on the PIKfyve inhibitor Apilimod and VHL ligand. It can effectively inhibit the autophagy pathway in a variety of prostate cancer cells by degrading PIKfyve, and significantly induce pronounced vacuolization of tumor cytoplasm. |
| M40700 | MS28 | MS28 is a PROTAC molecule that targets CDK4/6 and induces ubiquitin ligases in close proximity to Cyclin D1 and CDK4/6 with antitumor activity. |
| M40699 | KT-253 | KT-253 is a degradation agent that targets MDM2 and can be used in studies related to immune system disorders and a variety of tumors. |
| M40695 | ABBV-101 | ABBV-101 is a degradation agent that targets BTK and can be used in studies related to non-Hodgkin's lymphoma. |
| M40693 | ASP-3082 | ASP-3082 a potent, selective KRAS G12D protein degrader (PROTAC) for solid tumor related studies. |
| M40690 | CC-94676 | CC-94676 is an orally active androgen receptor (AR) degrader for studies related to solid tumors. |
| M40689 | CG001419 | CG001419 is a first-in-class neurotyrosine kinase receptor (TRK) degrader that can be used in a variety of tumor-related studies. |
| M31276 | PROTAC CDK2/9 Degrader-1 | PROTAC CDK2/9 Degrader-1 is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 µM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with Cereblon ligand. |
| M31078 | PROTAC AR Degrader-4 TFA | PROTAC AR Degrader-4 comprises a IAP ligand binding group, a linker and an Androgen Receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs). |
| M31077 | PZ703b TFA | PZ703b TFA is a Bcl-xl PROTAC degradation agent that induces apoptosis and inhibits cancer cell proliferation for bladder cancer research. |
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