Dovitinib RIBOTAC TFA is a targeted RNA degrader that cleaves pre-miR-21 with enhanced potency and selectivity.
Molecular Weight | 1120.13 |
Formula | C53H57F4N9O12S |
CAS Number | 2759351-69-2 |
Form | Solid |
Solubility (25°C) | DMSO 100 mg/mL (Need ultrasonic) |
Storage | 4°C, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Susana P Alves et al. Lipids. Trans-10 18:1 in ruminant meats: A review
[3] Jérôme Clerc. Q J Nucl Med Mol Imaging. Radioiodine therapy of thyroid autonomy
[5] Chaoyang Li et al. Prev Chronic Dis. Global Surveillance of trans-Fatty Acids
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