| Cat.No. | Name | Information |
|---|---|---|
| M43439 | Dovitinib-RIBOTAC TFA | Dovitinib RIBOTAC TFA is a targeted RNA degrader that cleaves pre-miR-21 with enhanced potency and selectivity. |
| M43438 | PROTAC TG2 degrader-2 | PROTAC TG2 degrader-2 is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with Kd > 100 μM. |
| M43437 | GBD-9 | GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). |
| M43436 | PROTAC TG2 degrader-1 | PROTAC TG2 degrader-1 is a von Hippel-Lindau (VHL)-based PROTAC targeting tissue transglutaminase (TG2) with a KD of 68.9 μM. |
| M43435 | PROTAC BRD4 Degrader-17 | PROTAC BRD4 Degrader-17 is a potent PROTAC BRD4 Degrader, with IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)). |
| M43434 | PROTAC BRD4 Degrader-16 | PROTAC BRD4 Degrader-16 is a potent PROTAC BRD4 Degrader, with IC50 values of 34.58 nM (BRD4 (BD1)) and 40.23 nM (BRD4 (BD2)). |
| M43433 | PROTAC BRAF-V600E degrader-2 | PROTAC BRAF-V600E degrader-2 is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. |
| M43432 | SIAIS164018 hydrochloride | SIAIS164018 hydrochloride is a PROTAC-based ALK and EGFR degrader, with IC50 value of 2.5 nM and 6.6 nM for ALK and ALK G1202R, respectively. |
| M43431 | PROTAC Her3 Degrader-8 | PROTAC Her3 Degrader-8 is a PROTAC that can degrade Her3 protein in vitro and cell experiments, and can be used to study diseases regulated by HER family proteins. |
| M43430 | PROTAC CDK12/13 Degrader-1 TFA | PROTAC CDK12/13 Degrader-1 TFA is a highly selective cell cycle protein-dependent kinase CDK12/CDK13 dual degrader with the DC50 values of 2.2 nM and 2.1 nM, respectively. |
| M43429 | PROTAC α-synuclein degrader 5 | PROTAC α-synuclein degrader 5 is a highly selective small-molecule degraders (PROTAC) of α-synuclein aggregates, with an DC50 of 7.51 μM and the highest degradation rate Dmax of 89%. |
| M41912 | PROTAC KRAS G12C degrader-2 | PROTAC KRAS G12C degrader-2 is a modulator of K-Ras protein hydrolysis. |
| M41727 | JET-209 | JET-209 is a potent PROTAC CBP/p300 degrader, with DC50 values of 0.05 nM and 0.2 nM for CBP and p300. |
| M41387 | JH-XII-03-02 | JH-XII-03-02 is a potent and selective LRRK2 PROTAC degrader. |
| M40745 | PIK5-12d | PIK5-12d is a highly active and selective PIKfyve degrader constructed based on the PIKfyve inhibitor Apilimod and VHL ligand. It can effectively inhibit the autophagy pathway in a variety of prostate cancer cells by degrading PIKfyve, and significantly induce pronounced vacuolization of tumor cytoplasm. |
| M40700 | MS28 | MS28 is a PROTAC molecule that targets CDK4/6 and induces ubiquitin ligases in close proximity to Cyclin D1 and CDK4/6 with antitumor activity. |
| M40699 | KT-253 | KT-253 is a degradation agent that targets MDM2 and can be used in studies related to immune system disorders and a variety of tumors. |
| M40698 | KT-333 | KT-333 is a heterobifunctional degradation agent (PROTAC) of the transcriptional regulator STAT3 and can be used in studies related to T-cell malignancies and solid tumors. |
| M40696 | KT-413 | KT-413 is a degradation agent that targets the IRAK4 protein and can be used in studies related to immune system diseases. |
| M40695 | ABBV-101 | ABBV-101 is a degradation agent that targets BTK and can be used in studies related to non-Hodgkin's lymphoma. |
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