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KP-14, a KRAS-PROTAC inhibitor with a similar structure to LC-2, inhibits the MAPK signaling pathway in NCI-H358 cells by binding to KRAS G12C via an acrylamide warhead and recruiting the E3 ligase CRBN, leading to rapid and sustained degradation of KRAS G12C. In addition, KP-14 exhibited potent antiproliferative activity against NCI-H358 cancer cells and was able to inhibit the formation of NCI-H358 tumor colonies, with an IC50 value of 17.41 μmol/L against the proliferation of NCI-H358 cells .
| Molecular Weight | 852.16 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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