About 6 results found for searched term "KP-14" (0.118 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M49369 | KP-14 | PROTAC |
| KP-14, a KRAS-PROTAC inhibitor with a similar structure to LC-2, inhibits the MAPK signaling pathway in NCI-H358 cells by binding to KRAS G12C via an acrylamide warhead and recruiting the E3 ligase CRBN, leading to rapid and sustained degradation of KRAS G12C. In addition, KP-14 exhibited potent antiproliferative activity against NCI-H358 cancer cells and was able to inhibit the formation of NCI-H358 tumor colonies, with an IC50 value of 17.41 μmol/L against the proliferation of NCI-H358 cells . | ||
| M6100 | Nivolumab | PD-1/PD-L1 |
| BMS-936558, ONO-4538, MDX-1106；Opdivo | ||
| Nivolumab (nabumab) is a fully humanized IgG4 monoclonal antibody against PD-1. It has immune checkpoint inhibitory activity and antitumor activity; MW: 143.597 KD.(for human-derived mice). | ||
| M6102 | Pembrolizumab | PD-1/PD-L1 |
| Lambrolizumab; MK-3475 | ||
| Pembrolizumab (pembrolizumab) is a humanized anti-PD-1 monoclonal antibody that blocks the interaction between PD-1 and its ligands PD-L1 and PD-L2. It has immune checkpoint inhibitory activity and antitumor activity. MW: 146.286 KD.(Pembrolizumab does not recognize murine PD-1 protein, humanized mice or mice expressing human PD-1 gene are required). | ||
| M10131 | Efinaconazole | Antibiotic |
| KP-103 | ||
| Efinaconazole (KP-103) is a triazole antifungal, it also acts as a 14α-demethylase inhibitor. | ||
| M41594 | CaMKP inhibitor sodium | ROCK |
| CaMKP inhibitor sodium is a selective inhibitor of ROCK1 with an IC50 value of 14 nM. | ||
| M49905 | KPH2f | URAT1 |
| KPH2f is an orally potent dual URAT1/GLUT9 inhibitor, with IC50s of 0.24 μM and 9.37 μM for URAT1 and GLUT9, respectively.KPH2f had little effect on OAT1 and ABCG2 (IC50s of 32.14 and 26.74 μM, respectively). | ||
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