About 2 results found for searched term "KP-14" (0.08 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3152 | Selinexor | CRM1 |
| KPT-330; ATG-010; 1421923-86-5 | ||
| Selinexor (KPT-330) is a first-in-class, oral, selective inhibitor of Nuclear Export (SINE) compound, works by binding to and inhibiting the nuclear export protein XPO1 (also known as CRM1). | ||
| M49369 | KP-14 | PROTAC |
| KP-14, a KRAS-PROTAC inhibitor with a similar structure to LC-2, inhibits the MAPK signaling pathway in NCI-H358 cells by binding to KRAS G12C via an acrylamide warhead and recruiting the E3 ligase CRBN, leading to rapid and sustained degradation of KRAS G12C. In addition, KP-14 exhibited potent antiproliferative activity against NCI-H358 cancer cells and was able to inhibit the formation of NCI-H358 tumor colonies, with an IC50 value of 17.41 μmol/L against the proliferation of NCI-H358 cells . | ||
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