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Biotin-PEG4-amino-t-Bu-DADPS-C6-azide

Cat. No. M21318
Biotin-PEG4-amino-t-Bu-DADPS-C6-azide  Structure
Synonym:

Biotin-Dadps-azide

Size Price Availability Quantity
5mg USD 350  USD350 In stock
10mg USD 550  USD550 In stock
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Quality Control & Documentation
Biological Activity

Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PROTAC linker, which belongs to the PEG class. It can be used for the synthesis of PROTAC molecules.*The compound is unstable in solutions, freshly prepared is recommended

Chemical Information
Molecular Weight 886.18
Formula C43H67N7O9SSi
CAS Number 1260247-50-4
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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  Catalog
Abmole Inhibitor Catalog




Keywords: Biotin-PEG4-amino-t-Bu-DADPS-C6-azide , Biotin-Dadps-azide supplier, PROTAC, inhibitors, activators


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