MTX-23

Cat. No. M57286

All AbMole products are for research use only, cannot be used for human consumption.

Synonym:

PROTAC AR-V7 degrader-2; MTX23

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MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis.

MTX-23 (0-20 μM; 4 d; 22Rvl cells) inhibits cell growth in dose-dependent manner. MTX-23 (10 μM; 4 d; 22Rvl cells) reduces AR-V7 protein levels.

MTX-23 (2.5 mg/mL; intratumor injection) inhibits tumor growth in nu/nu mice with 22Rvl-EnzR tumor xenografts.

Molecular Weight	882.05
Formula	C43H53F2N7O7S2
CAS Number	2488296-74-6
Solubility (25°C)	DMSO 90 mg/mL
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

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