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JQAD1 is a CRBN-dependent PROTAC that selectively targets EP300 for degradation. JQAD1 suppresses EP300 expression and the H3K27ac modification. JQAD1 induces apoptosis. JQAD1 can be used in research of cancer.
| Molecular Weight | 932.95 |
| Formula | C48H52F4N6O9 |
| CAS Number | 2417097-18-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PROTAC Products |
|---|
| ML 2-14
ML 2-14 is a E3-recruiting (RNF114, RNF4)-based PROTAC. ML 2-14 is targeting BRD4 with a C4 alkyl linker. ML 2-14 consists of the E3 ligase ligand EN219, the target protein ligand JQ-1, and the PROTAC linker. ML 2-14 can effectively degrade BRD4 in 231MFP breast cancer cells. |
| GDC-2992
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| Setidegrasib
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| PROTAC HK2 Degrader-1
PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. |
| ZXH-4-130 TFA
ZXH-4-130 TFA is a highly potent and selective degrader of CRBN. ZXH-4-130 is a CRBN-VHL compound (hetero-PROTAC). |
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