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TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM).
| Molecular Weight | 931.46 |
| Formula | C44H51ClN10O9S |
| CAS Number | 2250025-88-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 200 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light, dry, sealed |
| Related PROTAC Products |
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| Setidegrasib
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| PROTAC HK2 Degrader-1
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| ZXH-4-130 TFA
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| MS4322
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