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Cat. No. M4008
Liquiritigenin Structure


Size Price Availability Quantity
5mg USD 55  USD55 In stock
10mg USD 75  USD75 In stock
20mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc.

Chemical Information
Molecular Weight 256.25
Formula C15H12O4
CAS Number 578-86-9
Form Solid
Solubility (25°C) 150 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Mami Kato, et al. The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin

[2] Chang-Can Shi, et al. Development of liquiritigenin-phospholipid complex with the enhanced oral bioavailability

[3] Fang Liang, et al. Liquiritigenin decreases tumorigenesis by inhibiting DNMT activity and increasing BRCA1 transcriptional activity in triple-negative breast cancer

[4] Marta Carnovali, et al. Liquiritigenin reduces osteoclast activity in zebrafish model of glucocorticoid-induced osteoporosis

[5] Eun Hye Lee, et al. Liquiritigenin inhibits hepatic fibrogenesis and TGF-β1/Smad with Hippo/YAP signal

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Keywords: Liquiritigenin, 4',7-Dihydroxyflavanone supplier, Estrogen Receptor, inhibitors, activators

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