About 33 results found for searched term "CA inhibitor 2" (0.058 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8775 | DMAT | Others |
| Casein kinase II Inhibitor; CK2 Inhibitor | ||
| Casein kinase II inhibitor II (Ck2 Inhibitor II) is a high affinity ATP-competitive inhibitor of casein kinase II. | ||
| M21208 | BCATc Inhibitor 2 | Others |
| BCATc Inhibitor 2 is a sulfonyl hydrazide that inhibits BCATc with IC50s of 0.81 for human and IC50 s of 0.2 µM for rat. It is 15-fold selectivity over BCATm. It has also been used to block calcium influx into neurons with IC50 of 4.8 µM following inhibition of glutamate uptake and to demonstrate neuroprotective efficacy in an in vivo rat model of neurodegeneration. | ||
| M42298 | CA inhibitor 2 | Carbonic Anhydrase |
| CA inhibitor 2 is a carbonic anhydrase inhibitor (IC50: 0.033 μM). | ||
| M1814 | Avasimibe | Cytochrome P450 (e.g. CYP17) |
| CI-1011, PD 148515 | ||
| Avasimibe (CI-1011) is a novel orally bioavailable ACAT inhibitor with IC50 values of 2.9, 13.9, 26.5 µM for CYP2C9, CYP1A2 and CYP2C19, respectively. | ||
| M1903 | PF-4800567 | Casein Kinase |
| PF-4800567 is a selective, ATP competitive casein kinase 1ε inhibitor with IC50 values of 32 and 711 nM for CK1ε and CK1δ respectively. | ||
| M1923 | Lonidamine | CFTR |
| AF 1890；Diclondazolic Acid; DICA | ||
| Lonidamine (AF-1890) is a novel CFTR open channel blocker with an IC50 of 0.85 mM, which inhibits aerobic glycolysis in cancer cells. Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki=2.5 μM). | ||
| M1943 | Canertinib | EGFR/HER2 |
| CI-1033, PD-183805 | ||
| Canertinib (CI-1033) is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM). | ||
| M1985 | Odanacatib | Cathepsin |
| MK-0822 | ||
| Odanacatib (MK-0822) is a potent and reversible covalent inhibitor of CathepsinK (CatK) with an IC50 of 0.2 nM/1 nM for human/rabbit cathepsin B, L, and S and is highly selective. | ||
| M1992 | 2-Methoxyestradiol | HIF |
| 2ME2 | ||
| 2-methoxyestradiol (2-ME2), an endogenous metabolite of 17β -estradiol (E2) with oral activity, is an apoptosis inducer and angiogenesis inhibitor with effective antitumor activity. Methoxyestradiol can also destabilize microtubules. Methoxyestradiol is a potent inhibitor of superoxide dismutase (SOD) and reactive oxygen species (ROS) that can induce autophagy in transformed cell line HEK293, cancer cell line U87 and HeLa. | ||
| M2090 | MLN2480 | Raf |
| BIIB-024; Tovorafenib | ||
| MLN2480 is an orally active, CNS-permeable, highly selective inhibitor of type II RAF kinase that inhibits both monomeric (class I mutant) and dimeric forms of RAF and does not cause aberrant activation of the MAPK pathway caused by type I RAF inhibitors. In addition, MLN2480 inhibits the growth of tumors harboring BRAF fusions or BRAF V600 mutations and can be used in studies related to gliomas. | ||
| M2349 | (R)-Nepicastat hydrochloride | HCV Protease |
| RS-25560-198 HCl | ||
| (R)-Nepicastat hydrochloride, the R-enantiomer of Nepicastat hydrochloride, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. | ||
| M2152 | Carfilzomib | Proteasome |
| PR-171 | ||
| Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of <5 nM. Carfilzomib irreverently selectively binds to the active site containing n-terminal threonine of the 20S proteasome and proteolytic core particles of the 26S proteasome.*The compound is unstable in solutions, freshly prepared is recommended. | ||
| M2203 | Elbasvir | HCV Protease |
| MK-8742 | ||
| Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) replication complex inhibitor, with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively. | ||
| M2226 | Melatonin | Melatonin Receptor |
| Melatonex; N-Acetyl-5-methoxytryptamine; MT | ||
| Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation. | ||
| M2300 | TPCA-1 | IκB/IKK |
| TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM. | ||
| M2303 | Capivasertib (AZD5363) | Akt |
| AZD-5363 | ||
| Capivasertib (AZD5363) is a potentially first-in-class, orally effective pan-AKT inhibitor with strong inhibition against all three AKT isomers (AKT1/2/3) at an IC50 of 3 nM/8 nM/8 nM. It also showed similar inhibitory effect on P70S6K/PKA and low inhibitory activity on ROCK1/2. | ||
| M2597 | Betrixaban | Factor Xa |
| PRT-054021 | ||
| Betrixaban is a highly potent, selective, and orally efficacious factor Xa inhibitor with IC50 of 1.2 nM(inhibition of Factor 10a). | ||
| M2360 | 4E1RCat | Eukaryotic Initiation Factor |
| 4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM. | ||
| M2497 | Cathepsin Inhibitor 1 | Cathepsin |
| Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. | ||
| M2709 | Fluorometholone Acetate | Carbonic Anhydrase |
| Fluorometholone Acetate is a synthetic corticosteroid and a potent carbonic anhydrase (CA) inhibitor with IC50s of 2.18 μM for hCA-I and 17.5 μM for hCA-II. It has anti-inflammatory activity and may be used in studies related to steroid-responsive ocular inflammation. | ||
| M2960 | Probenecid | TRP Channel |
| Benemid | ||
| Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. | ||
| M2961 | Procaine hydrochloride | Sodium Channel |
| Novocaine HCl | ||
| Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M2972 | Q-VD-OPh | Caspase |
| QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone | ||
| Q-VD-OPh is a potent, irreversible pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. | ||
| M3064 | Thiamet G | OGA/OGT |
| Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal –hexosaminidase. | ||
| M3149 | CP-640186 | Acetyl-CoA Carboxylase |
| CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. | ||
| M3260 | Carbidopa | Aryl hydrocarbon Receptor |
| (S)-(-)-Carbidopa | ||
| Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM. | ||
| M3271 | Methyldopa | Adrenergic Receptor |
| MK-351; Methyldopa | ||
| Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg. | ||
| M3354 | Carbamazepine | Sodium Channel |
| CBZ; NSC 169864 | ||
| Carbamazepine is a sodium channel inhibitor with an IC50 of 131 μM when treated with synaptosomes in rat brain. It can be used in trigeminal neuralgia research. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50=2 μM). | ||
| M3595 | Gentamicin Sulfate | Animal Modeling |
| Gentamycin Sulfate; Gentacycol | ||
| Gentamicin Sulfate is a broad-spectrum aminoglycoside antibiotic that can be used in cell culture, as well as in the construction of animal models of chronic pelvic inflammatory disease. In addition, Gentamicin sulfate is also a potent DNase I inhibitor with an IC50 value of 0.57 ± 0.12 mM. | ||
| M3640 | BAY 57-1293 | Anti-infection |
| Pritelivir; AIC316 | ||
| BAY 57-1293 is a potent helicase primase inhibitor that exhibites antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2. | ||
| M3666 | Sofosbuvir (PSI-7977) | HCV Protease |
| Sofosbuvir, GS-7977 | ||
| Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM. | ||
| M3684 | Canertinib dihydrochloride | EGFR/HER2 |
| CI-1033 dihydrochloride, Canertinib 2HCl, PD-183805 dihydrochloride | ||
| Canertinib 2HCl is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. | ||
| M3880 | Acalisib | PI3K |
| GS-9820 | ||
| Acalisib (GS-9820) is a potent and selective PI3Kδ inhibitor with an IC50 of 12.7 nM, with potential immunomodulating and antineoplastic activities. | ||
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