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Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
Oncotarget. 2017 Apr 18;8(16):26992-27006.
Hispidin induces autophagic and necrotic death in SGC-7901 gastric cancer cells through lysosomal membrane permeabilization by inhibiting tubulin polymerization
Cathepsin Inhibitor 1 purchased from AbMole
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Source | Oncotarget (2017). Figure 3. Cathepsin inhibitor 1 (AbMole BioScience, Shanghai, China) |
| Method | MTT assay | |
| Cell Lines | SGC-7901 and GES-1 cells | |
| Concentrations | 122 μM | |
| Incubation Time | 2 h | |
| Results | As shown in Figure 3E, the cathepsin inhibitor 1, an inhibitor of Cathepsin L, Cathepsin L2, Cathepsin S, Cathepsin K and Cathepsin B, could not reduce hispidin-induced cell death. This indicates that cathepsins were not the real driver of the process. |
| Molecular Weight | 401.89 |
| Formula | C20H24ClN5O2 |
| CAS Number | 225120-65-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 70 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cathepsin Products |
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CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC50 value of 1.9 nM. |
| Z-Gly-Pro-Arg-AMC hydrochloride
Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. |
| N-CBZ-Phe-Arg-AMC
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes. |
| Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate, that can be used for cathepsin D FRET assay. |
| (S, S)-Z-FA-FMK
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. |
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