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CP 640186

Cat. No. M3149
CP 640186 Structure
Size Price Availability Quantity
2mg USD 80  USD80 In stock
5mg USD 120  USD120 In stock
10mg USD 190  USD190 In stock
50mg USD 650  USD650 In stock
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Quality Control & Documentation
Biological Activity

CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. CP-640186 inhibites fatty acid synthesis in rats, CD1 mice, and ob/ob mice with ED50s of 13, 11, and 4 mg/kg, and stimulated rat whole body fatty acid oxidation with an ED50 of ~30 mg/kg.

Product Citations
Customer Product Validations & Biological Datas
Source Am J Cancer Res 2020 Feb. Figure 4. CP-640186 (Abmole Bioscience, USA)
Method Western blot
Cell Lines ANGPTL4-/- mice
Concentrations -
Incubation Time -
Results Another reagent (CP-640186), an ACC1 inhibitor, also decreased the TNF-α and CD86 levels of ANGTPL4-/- macrophages to normal levels.
Chemical Information
Molecular Weight 485.62
Formula C30H35N3O3
CAS Number 591778-68-6
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Harwood HJ Jr, et al. J Biol Chem. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals.

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Abmole Inhibitor Catalog

Keywords: CP 640186 supplier, Acetyl-CoA Carboxylase, inhibitors, activators

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