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Cat. No. M21286

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PF-05221304 Structure


Size Price Availability Quantity
5mg USD 300  USD300 In stock
10mg USD 450  USD450 In stock
25mg USD 770  USD770 In stock
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Biological Activity

PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first step of adipogenesis ab initio (DNL).

Chemical Information
Molecular Weight 502.56
Formula C28H30N4O5
CAS Number 1370448-25-1
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month

[1] Tim F Ryder, et al. Xenobiotica. Pharmacokinetics, mass balance, metabolism, and excretion of the liver-targeted acetyl-CoA carboxylase inhibitor PF-05221304 (clesacostat) in humans

[2] Neeta B Amin, et al. BMJ Open. Efficacy and safety of an orally administered DGAT2 inhibitor alone or coadministered with a liver-targeted ACC inhibitor in adults with non-alcoholic steatohepatitis (NASH): rationale and design of the phase II, dose-ranging, dose-finding, randomised, placebo-controlled MIRNA (Metabolic Interventions to Resolve NASH with fibrosis) study

[3] Roberto A Calle, et al. Nat Med. ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials

[4] Trenton T Ross, et al. Cell Mol Gastroenterol Hepatol. Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems

[5] Arthur Bergman, et al. Clin Pharmacol Drug Dev. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Liver-Targeting Acetyl-CoA Carboxylase Inhibitor (PF-05221304): A Three-Part Randomized Phase 1 Study

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Abmole Inhibitor Catalog

Keywords: PF-05221304, Clesacostat supplier, Acetyl-CoA Carboxylase, inhibitors, activators

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