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Firsocostat (ND-630)

Cat. No. M8875

All AbMole products are for research use only, cannot be used for human consumption.

Firsocostat (ND-630) Structure
Synonym:

GS-0976; NDI-010976

Size Price Availability Quantity
5mg USD 225  USD225 In stock
10mg USD 375  USD375 In stock
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Quality Control & Documentation
Biological Activity

ND-630, also known as GS-0976 and NDI-010976, is a potent ACC inhibitor. ND-630 inhibits ACC activity by interacting within the phosphopeptide-acceptor and dimerization site of the enzyme to prevent dimerization. ND-630 inhibits fatty acid synthesis with an EC50 of 66 nM in HepG2 cells without altering the total cell number, cellular protein concentration, and incorporation of acetate into cholesterol.

Chronical administration of ND-630 to rats with diet-induced obesity reduces hepatic steatosis, improves insulin sensitivity, reduces weight gain without affecting food intake, and favorably affects dyslipidemia. Chronical administration of ND-630 Zucker diabetic fatty rats, ND-630 reduces hepatic steatosis, improves glucose-stimulated insulin secretion, and reduces hemoglobin A1c (0.9% reduction). ND-630 exhibits an aqueous solubility of 594 μM and human and rat plasma protein binding of 98.5% and 98.6%, respectively.

Chemical Information
Molecular Weight 569.63
Formula C28H31N3O8S
CAS Number 1434635-54-7
Solubility (25°C) DMSO ≥ 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Harriman G, et al. Proc Natl Acad Sci U S A. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.

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Keywords: Firsocostat (ND-630), GS-0976; NDI-010976 supplier, Acetyl-CoA Carboxylase, inhibitors, activators

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