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Capivasertib (AZD5363)

Cat. No. M2303

All AbMole products are for research use only, cannot be used for human consumption.

Capivasertib (AZD5363) Structure
Synonym:

AZD-5363

Size Price Availability Quantity
10mM*1mL in DMSO USD 70  USD70 In stock
1mg USD 33  USD33 In stock
5mg USD 69  USD69 In stock
10mg USD 110  USD110 In stock
25mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Capivasertib (AZD5363) is a potentially first-in-class, orally effective pan-AKT inhibitor with strong inhibition against all three AKT isomers (AKT1/2/3) at an IC50 of 3 nM/8 nM/8 nM. It also showed similar inhibitory effect on P70S6K/PKA and low inhibitory activity on ROCK1/2.

Product Citations
Customer Product Validations & Biological Datas
Source Oxid Med Cell Longev (2021). Figure 5. (Abmole Bioscience, USA)
Method Cell Culture and Treatment
Cell Lines HUVECs and bEnd.3 cells
Concentrations 100 μM
Incubation Time 4 h
Results We found that LY294002, AZD5363, rapamycin, and L-NAME pretreatment could significantly upregulate the expression of LC3-II, while downregulating the expression of p62 compared with the oxLDL/β2GPI/anti-β2GPI complex alone group
Source Cancer Biol Ther (2018). Figure 3. AZD5363
Method Western blot
Cell Lines HEK293T cells
Concentrations 250 mg/kg
Incubation Time 24 h
Results Proliferation of homozygous H2189Y mutant cells was significantly inhibited by the mTOR inhibitor everolimus (P =0.018), the PI3K inhibitor LY294002 (P D 0.016), and the AKT inhibitors AZD5363 (P = 0.009) and MK-2206 (P = 0.003). The PI3K inhibitor Wortmannin had no significant effect on proliferation in these five cell lines
Chemical Information
Molecular Weight 428.92
Formula C21H25ClN6O2
CAS Number 1143532-39-1
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Matt Addie, et al. J Med Chem. Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases

[2] Barry R Davies, et al. Mol Cancer Ther. Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background

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Keywords: Capivasertib (AZD5363), AZD-5363 supplier, Akt, inhibitors, activators

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