Akt Protein kinase B

Cat.No.	Name	Information
M22523	Recilisib sodium	Recilisib (ON 01210) sodium is a radioprotectant, which can activate AKT, PI3K activities in cells.
M5167	Calpeptin	Calpeptin is a potent, cell-permeable inhibitor of the Ca²⁺-dependent protease, calpain.
M5153	SC79	SC79 is a specific and BBB permeable Akt activator used to enhance Akt activity. SC79 activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt. *The compound is unstable in solutions, freshly prepared is recommended
M3068	TIC10	TIC10 (ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
M2303	Capivasertib (AZD5363)	Capivasertib (AZD5363) is a potentially first-in-class, orally effective pan-AKT inhibitor with strong inhibition against all three AKT isomers (AKT1/2/3) at an IC50 of 3 nM/8 nM/8 nM. It also showed similar inhibitory effect on P70S6K/PKA and low inhibitory activity on ROCK1/2.
M1837	MK-2206 2HCl	MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively.
M1823	Perifosine	Perifosine is an orally active Akt inhibitor, the antiproliferative properties of Perifosine with an IC50 of 0.6–8.9 µM.
M58584	(E)-Akt inhibitor-IV	(E)-Akt inhibitor-IV is a PI3K-Akt inhibitor, with potent cytotoxic.
M50435	Adropin (34-76) (human, mouse, rat)	Adropin (34-76) (human, mouse, rat) is a secretory domain of Adropin. Adropin (34-76) can inhibit cAMP level and glucose production in hepatocytes, and has a hypoglycemic effect. Adropin (34-76) plays an antifibrotic role by inhibiting the GLI1 signaling pathway.
M44752	6-Hydroxyflavone	6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity.
M43863	Chemerin-9 (149-157) acetate	Chemerin-9 (149-157) acetate is a potent chemokine-like receptor 1 (CMKLR1) agonist that stimulates the phosphorylation of Akt and ERK as well as the production of reactive oxygen species, ameliorates Aβ1-42-induced memory deficits, modulates the immune response, adipocyte differentiation, and glucose metabolism, and possesses anti-inflammatory activity.
M39834	Monomethyl lithospermate	Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis.
M22521	ZINC00640089	ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells.
M20677	Borussertib	Borussertib is a first-in-class covalently-mutated inhibitor of the protein kinase Akt, with an IC50 value of 0.8 nM and a Ki value of 2.2 nM for Akt^wt.
M19274	Crebanine	Crebanine, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect.
M18072	24-Methylene cycloartanyl ferulate	24-Methylene cycloartanyl ferulate
M17858	Niloticin	Niloticin is a osteoclastogenesis inhibitor. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways. Niloticin has anti-viral, antioxidative, and mosquitocidal activities.
M14835	CCT128930 hydrochloride	CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC₅₀=6 nM).
M14834	AT7867 dihydrochloride	AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.
M14833	AKT Kinase Inhibitor	AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity.

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Akt Protein kinase B

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