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Akt Protein kinase B

Inhibitors

Cat.No.  Name Information
M1837 MK-2206 2HCl MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively.
M3068 TIC10 TIC10 (ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
M1823 Perifosine Perifosine is an orally active Akt inhibitor, the antiproliferative properties of Perifosine with an IC50 of 0.6–8.9 µM.
M2303 AZD5363 (Capivasertib) AZD5363 is a potent Akt inhibitor for Akt1, Akt2 and Akt3 with IC50 of 3 nM, 8 nM and 8 nM, respectively.
M11229 Miransertib hydrochloride Miransertib hydrochloride (ARQ-092 Hydrochloride) is a potent, orally active, selective and allosteric Akt inhibitor with an IC50 of 2.7 nM for Akt1, Akt2, and Akt3, respectively. 14 nM and 8.1 nM. Miransertib hydrochloride is an effective inhibitor of AKT1-E17K mutant protein, and can be used in the study of PI3K/ AkT-driven tumors and Proteus syndrome. Miransertib hydrochloride effectively inhibited Leishmania.
M11228 BAY1125976 BAY1125976 is an Akt1/Akt2 selective allosteric inhibitor. The IC50 values of Akt1 and Akt2 inhibition at 10 μM ATP were 5.2 nM and 18 nM, respectively.
M11038 Crosstide Crosstide is a mimic peptide of glycogen synthase kinase α/β fusion protein sequences and is a substrate for Akt.
M11014 Recilisib Recilisib (ON01210) is a radiation protection agent that activates the activity of AKT and PI3K in cells.
M9945 Loureirin A Loureirin A is a flavonoid extracted from Dragon's Blood, it can inhibit Akt phosphorylation.
M9592 Theaflavin 3,3'-digallate Theaflavin 3,3'-digallate (TF3) is an antitumor agent. TF-3 has strong inhibitory effects on Dnmt3a and Dnmt3b.
M9024 Afuresertib hydrochloride Afuresertib hydrochloride is an orally bioavailable, potent and ATP-competitive inhibitor of the serine/threonine protein kinase Akt with potential antineoplastic activity.
M8909 Miransertib Miransertib, also known as ARQ 092, is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3).
M6044 Uprosertib (GSK2141795) Uprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1).
M5324 GDC-0068 (dihydrochloride) GDC-0068(RG 7440) 2Hcl is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA.
M5308 Afuresertib Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.
M5153 SC79 SC79 is an inhibitor of Akt-PH domain translocation and a specific Akt activator used to enhance Akt activity in various conditions.
M4988 AKT inhibitor VIII Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively).
M4806 AT-13148 AT-13148 is an oral, ATP-competitive inhibitor of multi-AGC kinases with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.
M4406 Phellodendrine Phellodendrine (Phellodendrine) is an isoquinoline alkaloid, which is one of the important characteristic components in cortex of Phellodendrine Phellodendrine. Phellodendrine regulates the AKT/NF-κB pathway to resist OXIDATIVE stress induced by AAPH. Phellodendrine has good antioxidant and anti-inflammatory effects.
M4364 Polyphyllin-VII Paris Saponin VII (Chonglou saponin VII) is a steroid saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim.
M4299 Pachymic-acid Pachymic-acid
M3941 Paeoniflorin Paeoniflorin is a glycoside isolated from the root of Paeonia lactiflora. Paeoniflorin has been used as an anticonvulsant and has hypoglycemic effect.
M3402 CCT128930 CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase.
M3377 Honokiol Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation.



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