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Akt Protein kinase B

Cat.No.  Name Information
M22523 Recilisib sodium Recilisib (ON 01210) sodium is a radioprotectant, which can activate AKT, PI3K activities in cells.
M5167 Calpeptin Calpeptin is a potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain.
M5153 SC79 SC79 is a specific and BBB permeable Akt activator used to enhance Akt activity. SC79 activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt. *The compound is unstable in solutions, freshly prepared is recommended
M3068 TIC10 TIC10 (ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
M2303 Capivasertib (AZD5363) Capivasertib (AZD5363) is a potentially first-in-class, orally effective pan-AKT inhibitor with strong inhibition against all three AKT isomers (AKT1/2/3) at an IC50 of 3 nM/8 nM/8 nM. It also showed similar inhibitory effect on P70S6K/PKA and low inhibitory activity on ROCK1/2.
M1837 MK-2206 2HCl MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively.
M1823 Perifosine Perifosine is an orally active Akt inhibitor, the antiproliferative properties of Perifosine with an IC50 of 0.6–8.9 µM.
M43863 Chemerin-9 (149-157) acetate Chemerin-9 (149-157) acetate is a potent chemokine-like receptor 1 (CMKLR1) agonist that stimulates the phosphorylation of Akt and ERK as well as the production of reactive oxygen species, ameliorates Aβ1-42-induced memory deficits, modulates the immune response, adipocyte differentiation, and glucose metabolism, and possesses anti-inflammatory activity.
M20677 Borussertib Borussertib is a first-in-class covalently-mutated inhibitor of the protein kinase Akt, with an IC50 value of 0.8 nM and a Ki value of 2.2 nM for Aktwt.
M19274 Crebanine Crebanine, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect.
M14835 CCT128930 hydrochloride CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC50=6 nM).
M14834 AT7867 dihydrochloride AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.
M14833 AKT Kinase Inhibitor AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity.
M14830 A-443654 A-443654 is a pan-Akt inhibitor and has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
M14677 CTX-0294885 CTX-0294885 is a a novel bisanilino pyrimidine; exhibits inhibitory activity against a broad range of kinases in vitro, and further developed it into a Sepharose-supported kinase capture reagent.
M11229 Miransertib hydrochloride Miransertib hydrochloride (ARQ-092 Hydrochloride) is a potent, orally active, selective and allosteric Akt inhibitor with an IC50 of 2.7 nM for Akt1, Akt2, and Akt3, respectively. 14 nM and 8.1 nM. Miransertib hydrochloride is an effective inhibitor of AKT1-E17K mutant protein, and can be used in the study of PI3K/ AkT-driven tumors and Proteus syndrome. Miransertib hydrochloride effectively inhibited Leishmania.
M11228 BAY1125976 BAY1125976 is an Akt1/Akt2 selective allosteric inhibitor. The IC50 values of Akt1 and Akt2 inhibition at 10 μM ATP were 5.2 nM and 18 nM, respectively.
M11014 Recilisib Recilisib (ON01210) is a radiation protection agent that activates the activity of AKT and PI3K in cells.
M9945 Loureirin A Loureirin A is a flavonoid extracted from Dragon's Blood, it can inhibit Akt phosphorylation.
M9592 Theaflavin 3,3'-digallate Theaflavin 3,3'-digallate (TF3) is an antitumor agent. TF-3 has strong inhibitory effects on Dnmt3a and Dnmt3b.




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