| Cat.No. | Name | Information |
|---|---|---|
| M1837 | MK-2206 2HCl | MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. |
| M3068 | TIC10 | TIC10 (ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. |
| M5167 | Calpeptin | Calpeptin is a potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. |
| M1823 | Perifosine | Perifosine is an orally active Akt inhibitor, the antiproliferative properties of Perifosine with an IC50 of 0.6–8.9 µM. |
| M2303 | Capivasertib (AZD5363) | Capivasertib (AZD5363) is a potentially first-in-class, orally effective pan-AKT inhibitor with strong inhibition against all three AKT isomers (AKT1/2/3) at an IC50 of 3 nM/8 nM/8 nM. It also showed similar inhibitory effect on P70S6K/PKA and low inhibitory activity on ROCK1/2. |
| M5153 | SC79 | SC79 is a specific and BBB permeable Akt activator used to enhance Akt activity. SC79 activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt. *The compound is unstable in solutions, freshly prepared is recommended |
| M22523 | Recilisib sodium | Recilisib (ON 01210) sodium is a radioprotectant, which can activate AKT, PI3K activities in cells. |
| M9024 | Afuresertib hydrochloride | Afuresertib hydrochloride is an orally bioavailable, potent and ATP-competitive inhibitor of the serine/threonine protein kinase Akt with potential antineoplastic activity. |
| M8909 | Miransertib | Miransertib, also known as ARQ 092, is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). |
| M6661 | Deguelin | Drillin is an anticancer and antiviral compound; Chemopreventive pro - apoptotic. |
| M6044 | Uprosertib (GSK2141795) | Uprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1). |
| M5324 | GDC-0068 dihydrochloride | GDC-0068(RG 7440) 2Hcl is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA. |
| M5308 | Afuresertib | Afuresertib (GSK2110183; LAE002) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. |
| M4988 | AKT inhibitor VIII | Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively). |
| M4806 | AT-13148 | AT-13148 is an oral, ATP-competitive inhibitor of multi-AGC kinases with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. |
| M4659 | Pinoresinol diglucoside | Pinoresinol Diglucoside is a major lignan isolated from eucommia ulmoides and other plant species and has a variety of pharmacological effects. |
| M4517 | Proanthocyanidins | Proanthocyanidins can be used as antioxidant and anti-cancers agent. Proanthocyanidin also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties. |
| M4406 | Phellodendrine | Phellodendrine (Phellodendrine) is an isoquinoline alkaloid, which is one of the important characteristic components in cortex of Phellodendrine Phellodendrine. Phellodendrine regulates the AKT/NF-κB pathway to resist OXIDATIVE stress induced by AAPH. Phellodendrine has good antioxidant and anti-inflammatory effects. |
| M4382 | Artemisinine | Artemisinin (Qinghaosu) is a kind of sesquiterpene lactone, an antimalarial drug isolated from the aboveground part of Artemisia annua L. Artemisinin inhibits AKT signaling by decreasing pAKT in a dose-dependent manner. Artemisinin can reduce the proliferation, migration, invasion, tumorigenesis and metastasis of cancer cells, and Artemisinin has neuroprotective effects. |
| M4364 | Polyphyllin-VII | Paris Saponin VII (Chonglou saponin VII) is a steroid saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. |
| M4299 | Pachymic-acid | Pachymic-acid |
| M3926 | Cynaroside | Cynaroside is a flavone, a flavonoid-like chemical compound. It is a 7-O-glucoside of luteolin. |
| M3402 | CCT128930 | CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. |
| M3377 | Honokiol | Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. |
| M2853 | Miltefosine | Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral compound for Visceral leishmaniasis, effective against both promastigotes and amastigotes. |
| M2149 | Astragaloside A | Astragaloside A is a novel regulator of HIF-1α and angiogenesis through the PI3K/Akt pathway in HUVECs. |
| M2132 | A-674563 | A-674563 is a potent, orally available PKB/Akt inhibitor with an IC50 of 14 nM. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
