Akt Protein kinase B

Cat.No.	Name	Information
M1837	MK-2206 2HCl	MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively.
M3068	TIC10	TIC10 (ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
M5167	Calpeptin	Calpeptin is a potent, cell-permeable inhibitor of the Ca²⁺-dependent protease, calpain.
M1823	Perifosine	Perifosine is an orally active Akt inhibitor, the antiproliferative properties of Perifosine with an IC50 of 0.6–8.9 µM.
M2303	Capivasertib (AZD5363)	Capivasertib (AZD5363) is a potentially first-in-class, orally effective pan-AKT inhibitor with strong inhibition against all three AKT isomers (AKT1/2/3) at an IC50 of 3 nM/8 nM/8 nM. It also showed similar inhibitory effect on P70S6K/PKA and low inhibitory activity on ROCK1/2.
M5153	SC79	SC79 is a specific and BBB permeable Akt activator used to enhance Akt activity. SC79 activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt. *The compound is unstable in solutions, freshly prepared is recommended
M22523	Recilisib sodium	Recilisib (ON 01210) sodium is a radioprotectant, which can activate AKT, PI3K activities in cells.
M4988	AKT inhibitor VIII	Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively).
M14831	A-674563 hydrochloride	A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM.
M14830	A-443654	A-443654 is a pan-Akt inhibitor and has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
M14677	CTX-0294885	CTX-0294885 is a a novel bisanilino pyrimidine; exhibits inhibitory activity against a broad range of kinases in vitro, and further developed it into a Sepharose-supported kinase capture reagent.
M11229	Miransertib hydrochloride	Miransertib hydrochloride (ARQ-092 Hydrochloride) is a potent, orally active, selective and allosteric Akt inhibitor with an IC50 of 2.7 nM for Akt1, Akt2, and Akt3, respectively. 14 nM and 8.1 nM. Miransertib hydrochloride is an effective inhibitor of AKT1-E17K mutant protein, and can be used in the study of PI3K/ AkT-driven tumors and Proteus syndrome. Miransertib hydrochloride effectively inhibited Leishmania.
M11228	BAY1125976	BAY1125976 is an Akt1/Akt2 selective allosteric inhibitor. The IC50 values of Akt1 and Akt2 inhibition at 10 μM ATP were 5.2 nM and 18 nM, respectively.
M11038	Crosstide	Crosstide is a mimic peptide of glycogen synthase kinase α/β fusion protein sequences and is a substrate for Akt.
M11014	Recilisib	Recilisib (ON01210) is a radiation protection agent that activates the activity of AKT and PI3K in cells.
M9945	Loureirin A	Loureirin A is a flavonoid extracted from Dragon's Blood, it can inhibit Akt phosphorylation.
M9592	Theaflavin 3,3'-digallate	Theaflavin 3,3'-digallate (TF3) is an antitumor agent. TF-3 has strong inhibitory effects on Dnmt3a and Dnmt3b.
M9024	Afuresertib hydrochloride	Afuresertib hydrochloride is an orally bioavailable, potent and ATP-competitive inhibitor of the serine/threonine protein kinase Akt with potential antineoplastic activity.
M8909	Miransertib	Miransertib, also known as ARQ 092, is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3).
M6661	Deguelin	Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.
M6044	Uprosertib (GSK2141795)	Uprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1).
M5324	GDC-0068 dihydrochloride	GDC-0068(RG 7440) 2Hcl is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA.
M5308	Afuresertib	Afuresertib (GSK2110183; LAE002) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively.
M4988	AKT inhibitor VIII	Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively).
M4806	AT-13148	AT-13148 is an oral, ATP-competitive inhibitor of multi-AGC kinases with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.
M4659	Pinoresinol diglucoside	Pinoresinol Diglucoside is a major lignan isolated from eucommia ulmoides and other plant species and has a variety of pharmacological effects.
M4517	Proanthocyanidins	Proanthocyanidins can be used as antioxidant and anti-cancers agent. Proanthocyanidin also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties.
M4406	Phellodendrine	Phellodendrine (Phellodendrine) is an isoquinoline alkaloid, which is one of the important characteristic components in cortex of Phellodendrine Phellodendrine. Phellodendrine regulates the AKT/NF-κB pathway to resist OXIDATIVE stress induced by AAPH. Phellodendrine has good antioxidant and anti-inflammatory effects.

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Akt Protein kinase B

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