Free shipping on all orders over $ 500

AKT inhibitor VIII

Cat. No. M4988
AKT inhibitor VIII Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 120  USD120 In stock
2mg USD 50  USD50 In stock
5mg USD 100  USD100 In stock
10mg USD 150  USD150 In stock
25mg USD 350  USD350 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Akt Inhibitor VIII does not exhibit any inhibitory effect against pleckstrin homology (PH) domain-lacking Akts, AGC family kinases, PKA, PKC or SGK. Akt Inhibitor VIII prevails over Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and has been shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 in cultured cells and in mice.

Chemical Information
Molecular Weight 551.64
Formula C34H29N7O
CAS Number 612847-09-3
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chao Liu, et al. Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling

[2] Dursun Gndz, et al. Role of PI3K/Akt and MEK/ERK Signalling in cAMP/Epac-Mediated Endothelial Barrier Stabilisation

[3] Congcong Yu, et al. Inhibition of AKT enhances the anti-cancer effects of Artemisinin in clear cell renal cell carcinoma

[4] Katrine Bjune, et al. Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms

[5] Yurong Tao, et al. AKT inhibitor suppresses hyperthermia-induced Ndrg2 phosphorylation in gastric cancer cells

Related Akt Products
LY2780301

LY2780301 is an oral dual-target inhibitor of AKT/RSK that binds to and inhibits the activity of Akt, thereby inhibiting the PI3K/Akt signaling pathway, which in turn inhibits cell proliferation and induces apoptosis in tumor cells, and possesses antitumor activity.

Akt/SKG Substrate Peptide

Akt/SKG Substrate Peptide is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1.

Adropin (34-76) (human, mouse, rat)

Adropin (34-76) (human, mouse, rat) regulates fuel selection preferences in skeletal muscle.

Apoptin-derived peptide

Apoptin-derived peptide is an antitumor polypeptide with cytotoxicity.

TAT-TCL1-Akt-in

TAT-TCL1-Akt-in is an Akt inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: AKT inhibitor VIII supplier, Akt, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.