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Recilisib sodium

Cat. No. M22523

All AbMole products are for research use only, cannot be used for human consumption.

Recilisib sodium Structure
Synonym:

ON-01210 sodium

Size Price Availability Quantity
2mg USD 55  USD55 In stock
5mg USD 99  USD99 In stock
10mg USD 142  USD142 In stock
25mg USD 230  USD230 In stock
50mg USD 395  USD395 In stock
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Quality Control & Documentation
Biological Activity

Recilisib (ON 01210) sodium is a radioprotectant, which can activate AKT, PI3K activities in cells. Recilisib Sodium (up to 50 µM) shows a normal distribution of cells throughout the cell cycle, with a slight reduction in the number of cells in S-phase at 50 µM. Recilisib Sodium provides dose dependent protection of human bone marrow cells at all three doses of IR. Recilisib Sodium activates the phosphorylation of AKT and GSK3α/β in HFL cells. Recilisib Sodium increases PI3K activity in HFL-1 cells and murine bone marrow cells in response to radiation exposure. Recilisib Sodium treatment in combination with radiation alters the MAPK signaling pathway.

In vivo, Recilisib Sodium (500 mg/kg) significantly increases the rate of recovery and differentiation of primitive bone marrow myeloid progenitor cells in mice. Recilisib Sodium in combination with radiation reduces CFU numbers in mice, but the Recilisib Sodium-treated mice consistently retain a capability to form differentiated colonies.

Product Citations
Chemical Information
Molecular Weight 358.77
Formula C16H12ClNaO4S
CAS Number 922139-31-9
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
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Keywords: Recilisib sodium, ON-01210 sodium supplier, Akt, inhibitors, activators

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