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Calpeptin is a potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Calpeptin inhibits 20K phosphorylation in a dose-related manner in platelets stimulated by thrombin, ionomycin or collagen. Calpeptin attenuates apoptosis, maintains normal whole-cell membrane potential in rat retinal ganglion cells, and thus provides functional neuroprotection. Calpeptin (0.6 mg/kg, i.v.) blocks the activation of calpain and caspase-3 in a feline right ventricular (RV) PO (RVPO) model, cleavage of their substrates, and cardiomyocyte programmed cell death.
Arthritis Res Ther. 2020 May 11;22(1):110.
Increased serum calpain activity is associated with HMGB1 levels in systemic sclerosis
Calpeptin purchased from AbMole
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Source | Arthritis Research & Therapy (2020 May). Figure 2. Calpeptin (Abmole Bioscience, USA) |
| Method | Calpain activity measurement | |
| Cell Lines | - | |
| Concentrations | 100 μM | |
| Incubation Time | 1 h | |
| Results | To further assess the relationship between serum calpain activity and HMGB1 in the pathogenesis of SSc, we evaluated whether serum calpain activity was correlated with serum HMGB1 level and found that serum calpain activity was correlated positively with HMGB1 level. |
| Molecular Weight | 362.46 |
| Formula | C20H30N2O4 |
| CAS Number | 117591-20-5 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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Products are for research use only. Not for human use. We do not sell to patients.
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