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Theaflavin 3,3'-digallate

Cat. No. M9592
Theaflavin 3,3'-digallate Structure
Synonym:

TF3

Size Price Availability Quantity
5mg USD 200  USD200 In stock
10mg USD 340  USD340 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Theaflavin 3,3'-digallate (TF3) is an antitumor agent. Theaflavin 3,3'-digallate inhibits HCT116 cell growth with an IC50 of 17.26 μM. Theaflavin 3,3'-digallate causes a rapid and sustained decrease in phospho-ERK1/2 and -MEK1/2 protein expression. TF-3 and EGCG have stronger inhibitory effects on Dnmt3a and Dnmt3b than on other methyltransferases. In addition, in silico analysis predicted that TF-3 would bind most specifically to the catalytic domain of Dnmt3a. Injection of TF-3 into control mice 6 weeks after OVX protected against bone loss, which was associated with a lower number of osteoclasts as compared to the numbers in vehicleinjected (saline) OVX mice, but TF-3 had a negligible effect on bone mass and osteoclast number in Dnmt3aRank−/− OVX mice compared to vehicle-injected Dnmt3aRank−/− OVX mice, indicating that, in osteoclasts, TF-3 exerts its effect specifically on Dnmt3a.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 868.7
Formula C43H32O20
CAS Number 30462-35-2
Purity >99%
Solubility DMSO ≥ 20 mg/mL
Storage -20°C, protect from light, dry, sealed
References

[1] Yangping Ding, et al. Food Nutr Res. Pre-treated theaflavin-3,3'-digallate Has a Higher Inhibitory Effect on the HCT116 Cell Line

[2] Keizo Nishikawa, et al. Nat Med. DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Theaflavin 3,3'-digallate, TF3 supplier, Akt, inhibitors

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