| Cat.No. | Name | Information |
|---|---|---|
| M1837 | MK-2206 2HCl | MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. |
| M3068 | TIC10 | TIC10 (ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. |
| M5167 | Calpeptin | Calpeptin is a potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. |
| M1823 | Perifosine | Perifosine is an orally active Akt inhibitor, the antiproliferative properties of Perifosine with an IC50 of 0.6–8.9 µM. |
| M2303 | Capivasertib (AZD5363) | Capivasertib (AZD5363) is a potentially first-in-class, orally effective pan-AKT inhibitor with strong inhibition against all three AKT isomers (AKT1/2/3) at an IC50 of 3 nM/8 nM/8 nM. It also showed similar inhibitory effect on P70S6K/PKA and low inhibitory activity on ROCK1/2. |
| M5153 | SC79 | SC79 is a specific and BBB permeable Akt activator used to enhance Akt activity. SC79 activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt. *The compound is unstable in solutions, freshly prepared is recommended |
| M22523 | Recilisib sodium | Recilisib (ON 01210) sodium is a radioprotectant, which can activate AKT, PI3K activities in cells. |
| M4988 | AKT inhibitor VIII | Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively). |
| M14832 | AKT-IN-1 | AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. |
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