| Cat.No. | Name | Information |
|---|---|---|
| M1837 | MK-2206 2HCl | MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. |
| M3068 | TIC10 | TIC10 (ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. |
| M5167 | Calpeptin | Calpeptin is a potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. |
| M1823 | Perifosine | Perifosine is an orally active Akt inhibitor, the antiproliferative properties of Perifosine with an IC50 of 0.6–8.9 µM. |
| M2303 | Capivasertib (AZD5363) | Capivasertib (AZD5363) is a potentially first-in-class, orally effective pan-AKT inhibitor with strong inhibition against all three AKT isomers (AKT1/2/3) at an IC50 of 3 nM/8 nM/8 nM. It also showed similar inhibitory effect on P70S6K/PKA and low inhibitory activity on ROCK1/2. |
| M5153 | SC79 | SC79 is a specific and BBB permeable Akt activator used to enhance Akt activity. SC79 activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt. *The compound is unstable in solutions, freshly prepared is recommended |
| M22523 | Recilisib sodium | Recilisib (ON 01210) sodium is a radioprotectant, which can activate AKT, PI3K activities in cells. |
| M28046 | MKC-1 | MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family. |
| M27712 | Uprosertib hydrochloride | Uprosertib hydrochloride (GSK2141795 hydrochloride) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively. |
| M27711 | GSK2110183 analog 1 | GSK2110183 analog 1 is the structural analogue of GSK2110183. |
| M27611 | PF-AKT400 | PF-AKT400 is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM). |
| M22521 | ZINC00640089 | ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. |
| M21373 | TAS-117 | TAS-117 is a potent, selective, orally active allosteric Akt inhibitor (IC50 of 4.8, 1.6 and 44 nM for Akt1, 2 and 3, respectively).TAS-117 stimulates anti-myeloma activity and enhances lethal endoplasmic reticulum stress induced by proteasome inhibition.TAS-117 induces apoptosis and autophagy. autophagy). |
| M21054 | NTQ1062 | NTQ1062 is an oral ATP-competitive Akt inhibitor being developed for cancer. |
| M20592 | TIC10 Analogue | TIC10 Analogue is an analogue of TIC10, which inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2. |
| M20376 | WAY-277364 | WAY-277364 is a Allosteric Akt inhibitor. |
| M20300 | WAY-603392 | WAY-603392 is a AKT(PKB) phosphorylation inhibitor |
| M18173 | 3,4,5-Tricaffeoylquinic acid | 3,4,5-Tricaffeoylquinic acid |
| M14832 | AKT-IN-1 | AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. |
| M14831 | A-674563 hydrochloride | A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM. |
| M11038 | Crosstide | Crosstide is a mimic peptide of glycogen synthase kinase α/β fusion protein sequences and is a substrate for Akt. |
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