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KP372-1 

Cat. No. M28281

All AbMole products are for research use only, cannot be used for human consumption.

KP372-1  Structure

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Quality Control & Documentation
Biological Activity

KP372-1 is an Akt inhibitor that inhibits proliferation and induces apoptosis and anoikis. KP372-1 is also an NQO1 redox cycling agent that causes DNA damage (including DNA breakage) by generating ROS. KP372-1 can be used in cancer research (such as head and neck squamous cell carcinoma (HNSCC) and pancreatic cancer).

Chemical Information
Molecular Weight 448.36
Formula C20H8N12O2
CAS Number 1374996-60-7
Form Solid
Solubility (25°C) DMSO 17.86 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lingxiang Jiang, et al. Front Oncol. KP372-1-Induced AKT Hyperactivation Blocks DNA Repair to Synergize With PARP Inhibitor Rucaparib via Inhibiting FOXO3a/GADD45α Pathway

[2] M Mandal, et al. Br J Cancer. Retraction Note to: The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells

[3] Talysa Viera, et al. Sci Rep. DNA damage induced by KP372-1 hyperactivates PARP1 and enhances lethality of pancreatic cancer cells with PARP inhibition

[4] A Österroos, et al. Biochem Pharmacol. Combination screening in vitro identifies synergistically acting KP372-1 and cytarabine against acute myeloid leukemia

[5] Yuzheng Zhao, et al. Cell Metab. SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents

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  Catalog
Abmole Inhibitor Catalog




Keywords: KP372-1  supplier, Akt, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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