Free shipping on all orders over $ 500

TAS-117

Cat. No. M21373

All AbMole products are for research use only, cannot be used for human consumption.

TAS-117 Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

TAS-117 is a potent, selective, orally active allosteric Akt inhibitor (IC50 of 4.8, 1.6 and 44 nM for Akt1, 2 and 3, respectively).TAS-117 stimulates anti-myeloma activity and enhances lethal endoplasmic reticulum stress induced by proteasome inhibition.TAS-117 induces apoptosis and autophagy. autophagy).

Chemical Information
Molecular Weight 424.49
Formula C26H24N4O2
CAS Number 1402602-94-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jordi Rodn, et al. Future Oncol. A phase II study of TAS-117 in patients with advanced solid tumors harboring germline PTEN-inactivating mutations

[2] Bruno Toson, et al. Pharmacol Res. Targeting Akt/PKB in pediatric tumors: A review from preclinical to clinical trials

[3] Naoya Mimura. Rinsho Ketsueki. [Novel epigenetic therapies for multiple myeloma]

[4] Jii Bum Lee, et al. Invest New Drugs. Phase 2 study of TAS-117, an allosteric akt inhibitor in advanced solid tumors harboring phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog gene mutations

[5] Naoya Mimura, et al. Cancer Res. Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition

Related Akt Products
(E)-Akt inhibitor-IV

(E)-Akt inhibitor-IV is a PI3K-Akt inhibitor, with potent cytotoxic.
K-80003

K-80003 is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth.
FPA-124 

FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM.
SPOP-IN-1 

SPOP-IN-1 is a selective SPOP E3 ubiquitin ligase inhibitor.
10-DEBC hydrochloride 

10-DEBC hydrochloride is a selective Akt inhibitor, with an IC50 of 1.28 μM.
  Catalog
Abmole Inhibitor Catalog




Keywords: TAS-117 supplier, Akt, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.