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MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family.
| Molecular Weight | 400.39 |
| Formula | C22H16N4O4 |
| CAS Number | 125313-92-0 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Flora Zagouri, et al. Gynecol Oncol. mTOR inhibitors in breast cancer: a systematic review
[5] A Tomillero, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials
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