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Akt3 degrader 1 

Cat. No. M29837

All AbMole products are for research use only, cannot be used for human consumption.

Akt3 degrader 1  Structure

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Quality Control & Documentation
Biological Activity

Akt3 degrader 1 (compound 12l) is a selective Akt3 degrader that overcomes Osimertinib-induced resistance in H1975OR NSCLC cells. Akt3 degrader 1 also has anti-proliferative activity and significantly inhibits tumour growth in mice. Akt3 degrader 1 can be used in the study of drug-resistant non-small cell lung cancer.

Chemical Information
Molecular Weight 885.19
Formula C53H72N8O4
CAS Number 2836342-69-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Patrick B Moloney, et al. Brain Commun. Epilepsy in the mTORopathies: opportunities for precision medicine

[2] Irene Benito-Cuesta, et al. Autophagy. AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on β-amyloid clearance

[3] Jun Xiao, et al. Immunity. Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection

[4] Nico Hinz, et al. Cell Commun Signal. Distinct functions of AKT isoforms in breast cancer: a comprehensive review

[5] Ying Zhang, et al. Cell Biosci. LncRNA MALAT1 promotes osteoarthritis by modulating miR-150-5p/AKT3 axis

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  Catalog
Abmole Inhibitor Catalog




Keywords: Akt3 degrader 1  supplier, Akt, inhibitors, activators

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