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3,4,5-Tricaffeoylquinic acid

Cat. No. M18173
3,4,5-Tricaffeoylquinic acid Structure
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Biological Activity

3,4,5-Tricaffeoylquinic acid

Chemical Information
Molecular Weight 678.59
Formula C34H30O15
CAS Number 86632-03-3
Form Solid
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Maizatul Hasyima Omar, et al. Int J Food Sci Nutr. In vitro catabolism of 3',4'-dihydroxycinnamic acid by human colonic microbiota

[2] Haoqiang Wan, et al. Food Chem Toxicol. 3,4,5-Tri-O-caffeoylquinic acid methyl ester isolated from Lonicera japonica Thunb. Flower buds facilitates hepatitis B virus replication in HepG2.2.15 cells

[3] Kazunori Sasaki, et al. Aging (Albany NY). 3,4,5-Tricaffeoylquinic acid induces adult neurogenesis and improves deficit of learning and memory in aging model senescence-accelerated prone 8 mice

[4] Da Hee Lee, et al. Phytother Res. 3,4,5-Tricaffeoylquinic Acid Attenuates TRAIL-induced Apoptosis in Human Keratinocytes by Suppressing Apoptosis-related Protein Activation

[5] Yoon Jeong Nam, et al. Neurochem Res. 3,4,5-tricaffeoylquinic acid attenuates proteasome inhibition-mediated programmed cell death in differentiated PC12 cells

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