Akt Protein kinase B

Cat.No.	Name	Information
M1837	MK-2206 2HCl	MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively.
M3068	TIC10	TIC10 (ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
M5167	Calpeptin	Calpeptin is a potent, cell-permeable inhibitor of the Ca²⁺-dependent protease, calpain.
M1823	Perifosine	Perifosine is an orally active Akt inhibitor, the antiproliferative properties of Perifosine with an IC50 of 0.6–8.9 µM.
M2303	Capivasertib (AZD5363)	Capivasertib (AZD5363) is a potentially first-in-class, orally effective pan-AKT inhibitor with strong inhibition against all three AKT isomers (AKT1/2/3) at an IC50 of 3 nM/8 nM/8 nM. It also showed similar inhibitory effect on P70S6K/PKA and low inhibitory activity on ROCK1/2.
M5153	SC79	SC79 is a specific and BBB permeable Akt activator used to enhance Akt activity. SC79 activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt. *The compound is unstable in solutions, freshly prepared is recommended
M22523	Recilisib sodium	Recilisib (ON 01210) sodium is a radioprotectant, which can activate AKT, PI3K activities in cells.
M4988	AKT inhibitor VIII	Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively).
M4382	Artemisinine	Artemisinin (Qinghaosu) is a kind of sesquiterpene lactone, an antimalarial drug isolated from the aboveground part of Artemisia annua L. Artemisinin inhibits AKT signaling by decreasing pAKT in a dose-dependent manner. Artemisinin can reduce the proliferation, migration, invasion, tumorigenesis and metastasis of cancer cells, and Artemisinin has neuroprotective effects.
M4364	Paris saponin VII	Paris saponin VII (Chonglou Saponin VII) is a steroid saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim.
M4299	Pachymic-acid	Pachymic-acid
M3926	Cynaroside	Cynaroside is a flavone, it is a 7-O-glucoside of luteolin that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM.
M3402	CCT128930	CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase.
M3377	Honokiol	Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation.
M2853	Miltefosine	Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral compound for Visceral leishmaniasis, effective against both promastigotes and amastigotes.
M2149	Astragaloside A	Astragaloside A is a novel regulator of HIF-1α and angiogenesis through the PI3K/Akt pathway in HUVECs.
M2132	A-674563	A-674563 is a potent, orally available PKB/Akt1 inhibitor with an IC50 of 11 nM.
M1900	PHT-427	PHT-427 is a novel dual Akt and PDPK1 inhibitor (Ki of 2.7 μM and 5.2 μM respectively).
M1884	Triciribine	Triciribine (API-2, NSC 154020) is a selective inhibitor of Akt (protein kinase B) signaling with IC50 of 130 nM.
M1862	Ipatasertib (GDC-0068)	GDC-0068 (RG7440) is a potent and selective, ATP-competitive Akt inhibitor with IC50 values of 5 to 18 nM.
M1789	GSK690693	GSK690693 is a potent Akt inhibitor (Akt1 IC50 = 2 nM, Akt2 IC50 = 13 nM, Akt3 IC50 = 9 nM) which also inhibited the phosphorylation of the downstream target GSK3b in cells.
M1654	AT7867	AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase with an IC50 of 17 nM.
M58519	K-80003	K-80003 is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth.
M57069	FPA-124	FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM.
M57068	SPOP-IN-1	SPOP-IN-1 is a selective SPOP E3 ubiquitin ligase inhibitor.
M57067	10-DEBC hydrochloride	10-DEBC hydrochloride is a selective Akt inhibitor, with an IC50 of 1.28 μM.
M57066	Pifusertib hydrochloride	Pifusertib (TAS-117) hydrochloride is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively).
M55856	BIBU1361	BIBU1361 induces apoptosis and inhibits autophagy.

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Akt Protein kinase B

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