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Astragaloside A is a pure small molecular compound isolated from Radix Astragali and is commonly used in the treatment of degenerative bone diseases such as osteoporosis. Administration of astragaloside A reduced blood pressure and triglyceride levels in fructose-fed rats and high dose of astragaloside A also improved glucose tolerance and endothelium-dependent vasorelaxation. The astragaloside A-induced improvement in vasorelaxation was associated with increased levels of aortic NOx and cGMP and was abrogated by blockade of nitric oxide synthase with NG-nitro-l-arginine methyl ester (l-NAME). Astragaloside A has a potent preventive action on myocardial fibrosis in CVB3-induced dilated cardiomyopathy that might be due to downregulation of TGF-β1-Smad signaling.
| Molecular Weight | 784.97 |
| Formula | C41H68O14 |
| CAS Number | 83207-58-3 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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