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Loureirin A

Cat. No. M9945
Loureirin A Structure
Size Price Availability Quantity
5mg USD 187  USD187 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Loureirin A is a flavonoid extracted from Dragon's Blood, it can inhibit Akt phosphorylation. Loureirin A significantly impairs platelet spreading on immobilized fibrinogen. Loureirin A (100 μM) almost completely eliminates collagen-induced Akt phosphorylation at Ser473, and has an additive inhibitory effect with the phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 on collage-induced Akt phosphorylation in platelets at 50 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 286.32
Formula C17H18O4
CAS Number 119425-89-7
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Sun-Li Hu, et al. Int Immunopharmacol. Downregulating Akt/NF-κB signaling and its antioxidant activity with Loureirin A for alleviating the progression of osteoarthritis: In vitro and vivo studies

[2] Hong-Zhen Hao, et al. Eur J Pharmacol. Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Loureirin A supplier, Akt, inhibitors

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