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ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00640089 (0.01-100 µM; 72 h) reduces cell proliferation and cell viability in SUM149 cells. ZINC00640089 (1, 10 µM; 15 min, 1 h) reduces the p-Akt levels in SUM149 cells. ZINC00640089 significantly decreased MCF7-LCN2 cell proliferation, suggesting the specificity of ZINC00640089 towards the LCN2-calyx.
| Molecular Weight | 370.32 |
| Formula | C20H13F3N2O2 |
| CAS Number | 667880-11-7 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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