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24-Methylene cycloartanyl ferulate

Cat. No. M18072
24-Methylene cycloartanyl ferulate Structure
Size Price Availability Quantity
5mg USD 360  USD360 In stock
10mg USD 590  USD590 In stock
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Biological Activity

24-Methylene cycloartanyl ferulate

Chemical Information
Molecular Weight 616.91
Formula C41H60O4
CAS Number 469-36-3
Form Solid
Solubility (25°C) DMSO ≥ 12 mg/mL
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] M S Sujith Kumar, et al. Indian J Biochem Biophys. Role of gamma-oryzanol in drought-tolerant and susceptible cultivars of rice (Oryza sativa L.)

[2] Weiying Lu, et al. Food Chem. Simultaneous HPLC quantification of five major triterpene alcohol and sterol ferulates in rice bran oil using a single reference standard

[3] Man Liu, et al. Food Chem. Preparative separation of triterpene alcohol ferulates from rice bran oil using a high performance counter-current chromatography

[4] Muhammad Zubair, et al. Int J Mol Sci. Characterization of high-value bioactives in some selected varieties of Pakistani Rice (Oryza sativa L.)

[5] Pramote Khuwijitjaru, et al. J Oleo Sci. Degradation kinetics of gamma-oryzanol in antioxidant-stripped rice bran oil during thermal oxidation

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