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Cat. No. M2597
Betrixaban Structure


Size Price Availability Quantity
10mM*1mL in DMSO USD 88  USD88 In stock
5mg USD 80  USD80 In stock
10mg USD 118  USD118 In stock
50mg USD 350  USD350 In stock
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Quality Control & Documentation
Biological Activity

Betrixaban is a highly potent, selective, and orally efficacious factor Xa inhibitor with IC50 of 1.2 nM(inhibition of Factor 10a).Betrixaban is an oral direct inhibitor being developed for the prevention of venous thromboembolism (VTE).Betrixaban demonstrates antithrombotic activity and appeared well tolerated in knee replacement patients at the doses studied.

Customer Product Validations & Biological Datas
Source Expert Opin Pharmacother (2013). Figure 2. Betrixaban
Method PK--PD analysis
Cell Lines
Concentrations 27.7 ng/mL and 58.6 ng/mL
Incubation Time 3.17 h
Results The median time of maximum plasma concentration (Tmax) for betrixaban occurred at 3.17 h after dosing for both dose groups
Source Expert Opin Pharmacother (2013). Figure 1. Betrixaban
Method PK--PD analysis
Cell Lines
Concentrations 27.7 ng/mL and 58.6 ng/mL
Incubation Time 3.17 h
Results The PK--PD modeling results demonstrated that betrixaban had no effect on cardiac repolarization
Protocol (for reference only)
Cell Experiment
Cell lines whole blood
Preparation method In a tissue factor-induced thrombin generation assay, betrixaban in concentrations ranging from 5 ng/mL to 25 ng/mL inhibited thrombin generation to a comparable degree as trough, and the peak levels were achieved by 2.5 mg fondaparinux.
Concentrations 5 ng/mL to 25 ng/mL
Incubation time 3–4 h
Animal Experiment
Animal models rabbit vena cava
Formulation 0.5% methylcellulose
Dosages 3 mg/kg
Administration i.v.
Chemical Information
Molecular Weight 451.91
Formula C23H22ClN5O3
CAS Number 330942-05-7
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Chan NC, et al. Vasc Health Risk Manag. Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism

[2] Turpie AG,et al. Thromb Haemost. A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT).

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Abmole Inhibitor Catalog

Keywords: Betrixaban, PRT-054021 supplier, Factor Xa, inhibitors, activators

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