Free shipping on all orders over $ 500

Edoxaban Tosylate Monohydrate

Cat. No. M2661
Edoxaban Tosylate Monohydrate Structure


Size Price Availability Quantity
5mg USD 75  USD75 In stock
10mg USD 115  USD115 In stock
50mg USD 420  USD420 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.

Customer Product Validations & Biological Datas
Source Thromb Res (2015). Figure 2. Edoxaban
Method Calibrated automated thrombogram assays
Cell Lines pooled citrated platelet-poor plasma
Concentrations 25 to 250 ng/mL
Incubation Time 15 min
Results A direct linear correlation was observed between plasma concentrations of edoxaban and the blood coagulation parameters PT ratio and INR across all thromboplastin reagents
Source Thromb Res (2015). Figure 1. Edoxaban
Method Thrombin generation test
Cell Lines pooled citrated platelet-poor plasma
Concentrations 0.02-3.65 μM
Incubation Time 15 min
Results Accordingly, the values of distributions of peak thrombin over time were significantly different between edoxaban and fondaparinux at the tested molar concentration (0.9 μM)
Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Incubation time
Animal Experiment
Animal models Venous stasis thrombosis model in rats and rabbits
Formulation 0.5% methylcellulose
Dosages 0.3–3 mg/kg (Rabbit); 0.5–12.5 mg/kg (Rat)
Administration p.o.
Chemical Information
Molecular Weight 738.27
Formula C24H30ClN7O4S.C7H8O3S.H2O
CAS Number 1229194-11-9
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Bounameaux H, et al. Drugs. Edoxaban: an update on the new oral direct factor Xa inhibitor.

[2] Mikkaichi T, et al. Drug Metab Dispos. Edoxaban transport via P-glycoprotein is a key factor for the drug's disposition.

Related Factor Xa Products

Milvexian (BMS-986177) is an orally bioavailable, reversible, direct inhibitor of human and rabbit factor (FXIa) with Ki values of 0.11 nM and 0.38 nM, respectively.


Asundexian (BAY2433334) is a reversible inhibitor of the active site of Factor XIa. Asundexian inhibits the activity of FXIa by directly, efficiently, and reversibly binding to its active site. the IC50 of human FXIa in Asundexian inhibition buffer is 1 nM.

Betrixaban maleate

Betrixaban maleate is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor

Edoxaban tosylate

Edoxaban tosylate (DU-176b) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively.


Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively.

Abmole Inhibitor Catalog

Keywords: Edoxaban Tosylate Monohydrate, DU-176b supplier, Factor Xa, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.