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Cat. No. M3335
Ozagrel Structure


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50mg USD 210  USD210 In stock
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Biological Activity

Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM. It does not inhibit prostacyclin (PGI2) synthetase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo. The beneficial effects of TXAS inhibition by ozagrel include improved motor coordination after experimental stroke and antihypertensive effects in spontaneously hypertensive rats.?

Chemical Information
Molecular Weight 228.25
Formula C13H12N2O2
CAS Number 82571-53-7
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Huiying Zhang, et al. Statistical analysis for efficacy of tirofiban combined with ozagrel in the treatment of progressive cerebral infarction patients out of thrombolytic therapy time window

[2] Vinayak Narayan, et al. Ozagrel for Postoperative Management of Aneurysmal Subarachnoid Hemorrhages

[3] Tomoki Wada, et al. Ozagrel for Patients With Noncardioembolic Ischemic Stroke: A Propensity Score-Matched Analysis

[4] Yasuhisa Kitagawa. Sodium ozagrel

[5] M Nakazawa, et al. Research and development of ozagrel, a highly selective inhibitor of TXA2 synthase

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Abmole Inhibitor Catalog

Keywords: Ozagrel, OKY-046 supplier, Factor Xa, inhibitors, activators

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