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Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM. It increases the plasma half-life of levodopa from 50 minutes to 1½ hours. CarbiDOPA cannot cross the blood brain barrier, so it inhibits only peripheral DDC. It thus prevents the conversion of L-DOPA to dopamine peripherally. This reduces the side effects caused by dopamine on the periphery,besides, it increases the concentration of L-DOPA and dopamine in the brain.
| Molecular Weight | 226.23 |
| Formula | C10H14N2O4 |
| CAS Number | 28860-95-9 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Sheridan M Hoy. Levodopa/Carbidopa Enteral Suspension: A Review in Advanced Parkinson's Disease
[4] Lauren C Seeberger, et al. Carbidopa levodopa enteral suspension
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