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Perillaldehyde

Cat. No. M8807
Perillaldehyde Structure
Synonym:

Perillal; PAE

Size Price Availability Quantity
25mg USD 81  USD90 In stock
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Quality Control
  • Current batch:
  • Purity Liquid
  • COA
  • MSDS
Biological Activity

Perillaldehyde inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 150.22
Formula C10H14O
CAS Number 18031-40-8
Purity Liquid
Solubility
Storage 2-8°C, sealed
References

Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes
Yoko Fuyuno, et al. Oxid Med Cell Longev. 2018 Feb 14;2018:9524657. PMID: 29643980.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Perillaldehyde, Perillal; PAE supplier, AhR, inhibitors

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