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StemRegenin 1

Cat. No. M2577
StemRegenin 1 Structure
Synonym:

SR1

Size Price Availability Quantity
5mg USD 40  USD40 In stock
10mg USD 60  USD60 In stock
25mg USD 125  USD125 In stock
50mg USD 210  USD210 In stock
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Quality Control & Documentation
Biological Activity

StemRegenin 1 is an AhR inhibitor with IC50 of 127 nM.

Chemical Information
Molecular Weight 429.54
Formula C24H23N5OS
CAS Number 1227633-49-9
Solubility (25°C) DMSO 66 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xuejun Zhu, et al. Reducing TGF-β1 cooperated with StemRegenin 1 promoted the expansion ex vivo of cord blood CD34 + cells by inhibiting AhR signalling

[2] Lihong Tao, et al. StemRegenin 1 selectively promotes expansion of Multipotent Hematopoietic Progenitors derived from Human Embryonic Stem Cells

[3] Carlo Stephan Jackson, et al. Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion

[4] John E Wagner Jr, et al. Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft

[5] Anthony E Boitano, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells

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Keywords: StemRegenin 1, SR1 supplier, Aryl hydrocarbon Receptor, inhibitors, activators


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