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Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties. Many biological effects of melatonin are produced through activation of melatonin receptors, while others are due to its role as a pervasive and powerful antioxidant, with a particular role in the protection of nuclear and mitochondrial DNA.
| Molecular Weight | 232.28 |
| Formula | C13H16N2O2 |
| CAS Number | 73-31-4 |
| Solubility (25°C) | DMSO 80 mg/mL Ethanol 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Sankha Bhattacharya, et al. Melatonin and its ubiquitous anticancer effects
[2] Susanna Esposito, et al. Pediatric sleep disturbances and treatment with melatonin
[3] Fernanda Gaspar do Amaral, et al. A brief review about melatonin, a pineal hormone
[4] B Claustrat, et al. Melatonin: Physiological effects in humans
[5] Armando L Morera-Fumero, et al. Role of melatonin in schizophrenia
| Related Melatonin Receptor Products |
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DH97 is a potent and selective antagonist of MT2 melatonin receptor, with a pKi of 8.03 for human MT2. |
| 8-M-PDOT
8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. |
| 6-Chloromelatonin
6-Chloromelatonin is a potent melatonin receptor agonist with greater metabolic stability than melatonin. |
| Melatonin-d4
Melatonin-d4 |
| Piromelatine
Piromelatine (Neu-P11) is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities. |
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