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 About 30 results found for searched term "RI-1" (0.002 seconds)

Cat.No.  Name Information
M1639 ABT-888 ABT-888 (Veliparib) is a potent inhibitor of PARP-1 and PARP-2 with Ki values of 5.2nM and 2.9nM respectively.
M1644 AG-014699 phosphate AG-014699 (PF-01367338, Rucaparib) is a PARP inhibitor with a Ki of 1.4 nM.
M1645 AG14361 AG14361 is a novel poly (ADP-ribose) polymerase-1 inhibitor with a GI50 of 10.9 µM.
M1664 AZD2281 (Olaparib) AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively.
M1687 Brivanib alaninate Brivanib alaninate (BMS-582664) is a novel, orally available and selective receptor tyrosine kinase inhibitor of VEGF-R2 and FGF-R1 and -2.
M1688 Brivanib Brivanib (BMS-540215) is a VEGFR -2 inhibitor with an IC50 value of 25 nM.
M1692 CHIR-99021 CHIR-99021 (CT99021) is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
M1704 Enzastaurin Enzastaurin inhibits PKCβ, PKCα, PKCγ and PKCε with IC50's of 0.006, 0.039, 0.083 and 0.110 µM, respectively.
M1710 Flavopiridol Flavopiridol (Alvocidib) is a competitive broad-spectrum CDK inhibitor with IC50 of 30,170,100 nM against CDK1, CDK2 and CDK4, respectively.
M1711 Febuxostat (TEI-6720) Febuxostat (TEI-6720) is a non-purine selective xanthine oxidase inhibitor with IC50 of 114 -210 nM.
M1729 H-89 Dihydrochloride H-89 dihydrochloride is a selective inhibitor of protein kinase A (PKA) with an IC50 value of 135 nM.
M1732 BMN673 (Talazoparib) Talazoparib (BMN-673) 是一种高效的,具有口服活性的 PARP 1/2 抑制剂。Talazoparib 抑制 PARP1 和 PARP2 酶活性的 Ki 值分别为 1.2 nM 和 0.87 nM。Talazoparib 具有抗肿瘤活性。
M1755 WYE-354 WYE-354 is a cell-permeable pyrazolopyrimidine compound that acts as a potent and ATP-competitive mTOR inhibitor (IC50 = 5 nM with S6K as the substrate and 100 µM ATP).
M1765 Crizotinib (PF-02341066) Crizotinib (PF-02341066) is a potent, orally bioavailable, ATP-competitive small-molecule inhibitor of c-Met kinase and ALK (anaplastic lymphoma kinase) with IC50 values to be 4 and 25 nM for C-Met and ALK resepectively.
M1770 PIK-75 Hydrochloride PIK-75 Hydrochloride is a PI3K p110α specific inhibitor with IC50s of 6,1300,76,510 nM for p110α,p110β,p110γ, p110δrespectively.
M1776 Rivaroxaban Rivaroxaban (Xarelto, BAY 59-7939) is oral direct factor Xa inhibitor with an IC50 value of 2.1nM.
M1780 Vorinostat Vorinostat (SAHA, Zolinza, MK-0683) is a selective and potent histone deacetylase (HDAC) inhibitor with the IC50 value of 10 nM for HDAC-1.
M1804 NVP-BSK805 dihydrochloride NVP-BSK805 dihydrochloride is a potent and selective quinoxaline JAK2 inhibitor with IC50 values of 0.48, 0.56 and 0.58 nM for JAK2 JH1, FL JAK V617F and FL JAK2 wt respectively.
M1824 SRT1720 Hydrochloride SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway.
M1837 MK-2206 2HCl MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively.
M1844 ITMN-191 ITMN-191 (Danoprevir, RG7227) is a potent and orally active inhibitor of hepatitis C virus (HCV) NS3/4A serine protease with an IC50 of 1.6 nM.
M1853 Biricodar The pipecolinate derivative Biricodar (VX-710, Incel) is a clinically applicable modulator of P-glycoprotein (Pgp) with potential chemosensitizing activity.
M1865 Bevirimat Bevirimat (BVM), also known as PA-457 or MPC-4326, is a novel Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor.
M1866 VU 0255035 VU 0255035 is a highly selective M1 muscarinic acetylcholine receptor (mAChR) antagonist (Ki = 14.87 nM).
M1872 Fasudil hydrochloride Fasudil hydrochloride is a potent Rho-associated kinase inhibitor with IC50 of 10.7 μM.
M1880 WY 14643 (Pirinixic Acid) WY 14643 (Pirinixic Acid) is a potent and selective, peroxisome proliferator-activated receptor-α (PPARα) agonist.
M1884 Triciribine Triciribine (API-2, NSC 154020) is a selective inhibitor of Akt (protein kinase B) signaling with IC50 of 130 nM.
M1891 SKF 89976A hydrochloride SKF 89976A hydrochloride is a potent GABA uptake inhibitor, selective for GAT-1.
M1898 Plerixafor Plerixafor (AMD3100) is a CXCR4 chemokine receptor antagonist.
M1905 PD318088 PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor.


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