About 30 results found for searched term "RI-1" (0.025 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1765 | Crizotinib (PF-02341066) | c-Met |
| Crizotinib | ||
| Crizotinib (PF-02341066) is a potent, orally bioavailable, ATP-competitive small-molecule inhibitor of c-Met kinase and ALK (anaplastic lymphoma kinase) with IC50 values to be 4 and 25 nM for C-Met and ALK resepectively. | ||
| M1880 | WY 14643 (Pirinixic Acid) | PPAR |
| Pirinixic Acid; NSC 310038 | ||
| WY 14643 (Pirinixic Acid) is a potent and selective, peroxisome proliferator-activated receptor-α (PPARα) agonist. | ||
| M1898 | Plerixafor (AMD3100) | CXCR |
| AMD3100; JM3100; ID791; AMD-3329 | ||
| Plerixafor (AMD3100) is a CXCR4 chemokine receptor antagonist. | ||
| M1956 | Apatinib mesylate | VEGFR/PDGFR |
| Rivoceranib mesylate; YN968D1 | ||
| Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor of VEGFR2 with an IC50 of 2.43 nM. | ||
| M1968 | Riluzole | Sodium Channel |
| Rilutek, PK-26124, RP-54274 | ||
| Rilutek is a sodium channel protein inhibitor and a new mental compound, which has anticonvulsant, hypnotic, antianxiety, antiischemia and anesthesia properties. Riluzole belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM. | ||
| M2161 | SCH527123 | CXCR |
| Navarixin; MK-7123 | ||
| SCH527123 is a novel, selective CXCR2 receptor antagonist with IC50 of 3 nM. | ||
| M2218 | Ribociclib (LEE011) | CDK |
| Ribociclib | ||
| Ribociclib (LEE011) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is 1000 times less active against cyclin B/CDK1 complex. | ||
| M2228 | Abitrexate (Methotrexate) | Antifolate |
| Amethopterin; CL14377; WR19039 | ||
| Abitrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. | ||
| M2276 | Torin 1 | mTOR |
| Torin 1 is a potent and selective inhibitor of mTOR with IC50 of 2 and 10 nM for mTORC1 and mTORC2, respectively. | ||
| M2327 | Daunorubicin hydrochloride | DNA/RNA Synthesis |
| Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride | ||
| Daunorubicin (Daunomycin) HCl is a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. | ||
| M2408 | Atomoxetine hydrochloride | 5-HT Receptor |
| Tomoxetine hydrochloride; LY 139603; (R)-Tomoxetine hydrochloride | ||
| Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters. | ||
| M2468 | Brimonidine Tartrate | Adrenergic Receptor |
| Brimonidine tartrate; AGN190342 tartrate; UK14304 tartrate | ||
| Brimonidine Tartrate is a highly selective α-adrenergic receptor antagonist with an EC50 of 0.45 nM for α2A adrenoreceptor, and has been used to study open-angle glaucoma or ocular hypertension. | ||
| M2504 | CFTRinh-172 | CFTR |
| CFTR inhibitor 172 | ||
| CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. | ||
| M2809 | Levobetaxolol hydrochloride | Adrenergic Receptor |
| (S)-Betaxolol hydrochloride; AL-1577A | ||
| Levobetaxolol exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively. | ||
| M2830 | Mdivi-1 | Dynamin |
| Mitochondrial division inhibitor 1 | ||
| Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. | ||
| M2838 | Meptazinol hydrochloride | Opioid Receptor |
| IL-22811 hydrochloride; WY-22811 hydrochloride | ||
| Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM. | ||
| M2978 | RI-1 | RAD51 |
| RAD51 inhibitor 1 | ||
| RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM. | ||
| M3002 | Scriptaid | HDAC |
| Scriptide; GCK1026 | ||
| Scriptaid is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3. | ||
| M3046 | Tacrine hydrochloride | AChR/AChE |
| Hydroaminacrine; NSC72108 HCl | ||
| Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist. | ||
| M3222 | Peramivir Trihydrate | Anti-infection |
| BCX-1812 Trihydrate; RWJ-270201 Trihydrate; S-021812 Trihydrate | ||
| Peramivir Trihydrate is a trihydrate of the anti-infection agent peramivir (RWJ-270201,BCX-1812) which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM. | ||
| M3379 | Trifluridine | DNA/RNA Synthesis |
| Trifluridine; FTD; 5-Trifluorothymidine; NSC 529182; NSC 75520 | ||
| Trifluridine (Viroptic) is an anti-herpesvirus antiviral agent used primarily on the eye. | ||
| M3547 | Glibenclamide | Others |
| Glyburide; RP-1127; BIIB093 | ||
| Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR). | ||
| M3640 | BAY 57-1293 | Anti-infection |
| Pritelivir; AIC316 | ||
| BAY 57-1293 is a potent helicase primase inhibitor that exhibites antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2. | ||
| M3684 | Canertinib dihydrochloride | EGFR/HER2 |
| CI-1033 dihydrochloride, Canertinib 2HCl, PD-183805 dihydrochloride | ||
| Canertinib 2HCl is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. | ||
| M3708 | Anastrozole | Cytochrome P450 (e.g. CYP17) |
| Arimidex, ZD1033 | ||
| Anastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. | ||
| M3877 | 4-Chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine | Others |
| 4-Chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine | ||
| M3933 | Danazol | Androgen Receptor |
| Danocrine, NSC 270916 | ||
| Danazol is a derivative of the synthetic steroid ethisterone that suppresses the production of gonadotrophins and has some weak androgenic effects. | ||
| M3921 | Dioscin | Autophagy |
| CCRIS 4123, Collettiside III | ||
| Dioscin (CCRIS 4123, Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines. | ||
| M4465 | Irinotecan | Topoisomerase |
| (+)-Irinotecan; CPT-11; VAL-413 | ||
| Irinotecan is an inhibitor of Topoisomerase I, and is is activated by hydrolysis to SN-38 (the active metabolite of Irinotecan). | ||
| M4553 | Tangeretin | Notch |
| Tangeritin; NSC53909; NSC618905; Ponkanetin | ||
| Tangeretin is a flavonoid from citrus fruit peels, and is also selected as a Notch-1 inhibitor, which plays an important role in anti-inflammatory responses and neuroprotective effects in several disease models. | ||
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