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RI-1

Cat. No. M2978
RI-1 Structure
Synonym:

RAD51 inhibitor 1

Size Price Availability Quantity
2mg USD 50  USD50 In stock
5mg USD 72  USD72 In stock
10mg USD 122  USD122 In stock
25mg USD 190  USD190 In stock
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Quality Control
Biological Activity

RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.

Product Citations
Customer Product Validations & Biological Datas
Source Sci Rep (2018). Figure 4. RI-1
Method Histochemical staining of GUS activity in rice cells and leaves
Cell Lines rice cells and leaves
Concentrations 1.0 × 10^10 CFU/mL
Incubation Time 1, 12, and 24 h
Results As shown in Fig. 4, compared with the levels observed in the WT plants, the relative expression levels of OsPR1, OsPR4, and OsPR10a were significantly up-regulated (P < 0.01) in the OEtr-1 lines but down regulated in the Ri-1 plants, whereas the expression of OsLOX and OsPAL was unaffected.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 361.61
Formula C14H11Cl3N2O3
CAS Number 415713-60-9
Purity >99%
Solubility DMSO 40 mg/mL
Storage at -20°C
References

[1] Wei Du, et al. Numerical Study of Graphene/Au/SiC Waveguide-Based Surface Plasmon Resonance Sensor

[2] Antonio Valado Cardoso. An experimental erythrocyte rigidity index (Ri) and its correlations with Transcranial Doppler velocities (TAMMV), Gosling Pulsatility Index PI, hematocrit, hemoglobin concentration and red cell distribution width (RDW)

[3] Brian Budke, et al. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells

[4] Piotr Golec, et al. A role for accessory genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4

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Keywords: RI-1, RAD51 inhibitor 1 supplier, RAD51, inhibitors

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