All AbMole products are for research use only, cannot be used for human consumption.
RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.
Free Radic Biol Med. 2022 Jan;178:174-188.
DNA damage response proteins synergistically affect the cancer prognosis and resistance
RI-1 purchased from AbMole
BMC Biol. 2021 May 20;19(1):108.
Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans
RI-1 purchased from AbMole
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Source | Sci Rep (2018). Figure 4. RI-1 |
| Method | Histochemical staining of GUS activity in rice cells and leaves | |
| Cell Lines | rice cells and leaves | |
| Concentrations | 1.0 × 10^10 CFU/mL | |
| Incubation Time | 1, 12, and 24 h | |
| Results | As shown in Fig. 4, compared with the levels observed in the WT plants, the relative expression levels of OsPR1, OsPR4, and OsPR10a were significantly up-regulated (P < 0.01) in the OEtr-1 lines but down regulated in the Ri-1 plants, whereas the expression of OsLOX and OsPAL was unaffected. |
| Molecular Weight | 361.61 |
| Formula | C14H11Cl3N2O3 |
| CAS Number | 415713-60-9 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related RAD51 Products |
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| RAD51-IN-3
RAD51-IN-3 is a Rad51 inhibitor. |
| DIDS
DIDS is a potent RAD51 inhibitor. DIDS inhibits the RAD51-mediated homologous pairing and strand-exchange reactions. DIDS inhibits anion exchange and binding to the red blood cell membrane. |
| CAM833
CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization. |
| IBR2
IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. |
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