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RI-1

Cat. No. M2978
RI-1 Structure
Synonym:

RAD51 inhibitor 1

Size Price Availability Quantity
2mg USD 50  USD50 In stock
5mg USD 72  USD72 In stock
10mg USD 122  USD122 In stock
25mg USD 190  USD190 In stock
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Quality Control & Documentation
Biological Activity

RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.

Product Citations
Customer Product Validations & Biological Datas
Source Sci Rep (2018). Figure 4. RI-1
Method Histochemical staining of GUS activity in rice cells and leaves
Cell Lines rice cells and leaves
Concentrations 1.0 × 10^10 CFU/mL
Incubation Time 1, 12, and 24 h
Results As shown in Fig. 4, compared with the levels observed in the WT plants, the relative expression levels of OsPR1, OsPR4, and OsPR10a were significantly up-regulated (P < 0.01) in the OEtr-1 lines but down regulated in the Ri-1 plants, whereas the expression of OsLOX and OsPAL was unaffected.
Chemical Information
Molecular Weight 361.61
Formula C14H11Cl3N2O3
CAS Number 415713-60-9
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wei Du, et al. Numerical Study of Graphene/Au/SiC Waveguide-Based Surface Plasmon Resonance Sensor

[2] Antonio Valado Cardoso. An experimental erythrocyte rigidity index (Ri) and its correlations with Transcranial Doppler velocities (TAMMV), Gosling Pulsatility Index PI, hematocrit, hemoglobin concentration and red cell distribution width (RDW)

[3] Brian Budke, et al. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells

[4] Piotr Golec, et al. A role for accessory genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4

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Keywords: RI-1, RAD51 inhibitor 1 supplier, RAD51, inhibitors, activators


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