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IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis.
| Molecular Weight | 400.49 |
| CAS Number | 313526-24-8 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Xiao-Long Qiu, et al. J Org Chem. Stereoselective synthesis of chiral IBR2 analogues
| Related RAD51 Products |
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| RAD51-IN-3
RAD51-IN-3 is a Rad51 inhibitor. |
| DIDS
DIDS is a potent RAD51 inhibitor. DIDS inhibits the RAD51-mediated homologous pairing and strand-exchange reactions. DIDS inhibits anion exchange and binding to the red blood cell membrane. |
| CAM833
CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization. |
| RI-1
RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM. |
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