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Tacrine hydrochloride

Cat. No. M3046
Tacrine hydrochloride Structure
Synonym:

Hydroaminacrine; NSC72108 HCl

Size Price Availability Quantity
100mg USD 67.5  USD75 In stock
500mg USD 157.5  USD175 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist. Tacrine also inhibits the uptake of serotonin and norepinephrine in rat cerebral cortex and reduces depolarization-induced calcium influx through L-type calcium channels in SN56 neuronal cells. Tacrine hydrochloride has been shown to inhibit acetylcholinesterase (AChE) with IC50 of 31 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 234.72
Formula C13H14N2.HCl
CAS Number 1684-40-8
Purity >98%
Solubility DMSO 40 mg/mL
Water 40 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tacrine hydrochloride, Hydroaminacrine; NSC72108 HCl supplier, AChR/AChE, inhibitors

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