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Verapamil hydrochloride

Cat. No. M3118

All AbMole products are for research use only, cannot be used for human consumption.

Verapamil hydrochloride Structure
Synonym:

(±)-Verapamil hydrochlorid

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
500mg USD 35  USD35 In stock
1g USD 50  USD50 In stock
5g USD 140  USD140 In stock
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Quality Control & Documentation
Biological Activity

Verapamil hydrochloride (VPH) is an orally active L-type calcium channel inhibitor that eliminates calcium channel agonist-induced calcium inward flow and apoptosis. In addition, Verapamil HCl also inhibits voltage-dependent K(+) (Kv) channels, decreasing Kv current amplitude in a concentration-dependent manner, with an apparent K(d) value of 0.82 for inhibition of Kv channels. Verapamil hydrochloride is a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil inhibits CAT1-mediated transport in an uncompetitive manner which is most likely related to its known effect on the membrane potential. Verapamil inhibited CAT1-mediated uptake of l-arginine, l-homoarginine, and ADMA with IC50 values of 85.3, 58.1, and 113 µM, respectively.

Chemical Information
Molecular Weight 491.06
Formula C27H38N2O4.HCl
CAS Number 152-11-4
Solubility (25°C) Water 40 mg/mL
DMSO 30 mg/mL
Storage -20°C, protect from light, dry, sealed
References

[1] Sofna Banjarnahor, et al. Amino Acids. Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of L-arginine and arginine derivatives

[2] Shuangjiao Sun, et al. Determination of Verapamil Hydrochloride and Norverapamil Hydrochloride in Rat Plasma by Capillary Electrophoresis With End-Column Electrochemiluminescence Detection and Their Pharmacokinetics Study

[3] Syam Krishna, et al. Degradation of Verapamil hydrochloride in water by gliding arc discharge

[4] Monika Kaur, et al. Microneedle-assisted delivery of verapamil hydrochloride and amlodipine besylate

[5] S H Baky, et al. Verapamil hydrochloride: pharmacological properties and role in cardiovascular therapeutics

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Keywords: Verapamil hydrochloride, (±)-Verapamil hydrochlorid supplier, Calcium Channel, inhibitors, activators

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