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Verapamil hydrochloride

Cat. No. M3118
Verapamil hydrochloride Structure
Synonym:

(±)-Verapamil hydrochlorid

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 28  USD28 In stock
500mg USD 46  USD46 In stock
1g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Verapamil hydrochloride (VPH) is an orally active L-type calcium channel inhibitor that eliminates calcium channel agonist-induced calcium inward flow and apoptosis. In addition, Verapamil HCl also inhibits voltage-dependent K(+) (Kv) channels, decreasing Kv current amplitude in a concentration-dependent manner, with an apparent K(d) value of 0.82 for inhibition of Kv channels. Verapamil hydrochloride is a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4.

Chemical Information
Molecular Weight 491.06
Formula C27H38N2O4.HCl
CAS Number 152-11-4
Solubility (25°C) Water 40 mg/mL
DMSO 30 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shuangjiao Sun, et al. Determination of Verapamil Hydrochloride and Norverapamil Hydrochloride in Rat Plasma by Capillary Electrophoresis With End-Column Electrochemiluminescence Detection and Their Pharmacokinetics Study

[2] Syam Krishna, et al. Degradation of Verapamil hydrochloride in water by gliding arc discharge

[3] Monika Kaur, et al. Microneedle-assisted delivery of verapamil hydrochloride and amlodipine besylate

[4] Victor Cohen, et al. Tarka® (trandolapril/verapamil hydrochloride extended-release) overdose

[5] S H Baky, et al. Verapamil hydrochloride: pharmacological properties and role in cardiovascular therapeutics

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Keywords: Verapamil hydrochloride, (±)-Verapamil hydrochlorid supplier, Calcium Channel, inhibitors, activators


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