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Methotrexate (Amethopterin) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate (Amethopterin) inhibits dihydrofolate reductase (DHFR), resulting in inhibition of purine nucleotide and thymidylate synthesis. Methotrexate (Amethopterin) performed growth inhibitory activity with median IC50 78 nM in a panel of six pediatric leukemia and lymphoma cell lines.
| Molecular Weight | 454.44 |
| Formula | C20H22N8O5 |
| CAS Number | 59-05-2 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
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