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Pralatrexate (Folotyn) is an antifolate, and structurally a folate analog. It acts as an inhibitor of dihydrofolate reductase. It is selective for the reduced folate carrier type 1. Its IC50 is < 300 nM in some cell lines.
| Molecular Weight | 477.47 |
| Formula | C23H23N7O5 |
| CAS Number | 146464-95-1 |
| Solubility (25°C) | DMSO 27 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] No authors listed. Pralatrexate
[3] No authors listed. Aust Prescr. Pralatrexate for lymphoma
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| Methotrexate α-tert-butyl ester
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| Trimetrexate glucuronate
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