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Folinic acid calcium salt

Cat. No. M2711
Folinic acid calcium salt Structure
Synonym:

Leucovorin

Size Price Availability Quantity
50mg In DMSO USD 40 In stock
100mg USD 52 In stock
200mg USD 80 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Folinic acid is an adjuvant used in cancer chemotherapy involving the compound methotrexate. Folinic acid serves as a cofactor and participates in one-carbon-transfer reactions. It helps in improving wound healing in rats. Folinic acid calcium salt has been used in the preparation of topical 1% and 2.5% folinic acid creams for use in wound healing studies. It has also been used as a component in the chemically defined-Chinese hamster ovary medium (CD-CHO) to culture CHO DUKX B11.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 511.50
Formula C20H21N7O7.Ca
CAS Number 1492-18-8
Purity >99%
Solubility Water ≥ 50 mg/mL
Storage 4°C, dry, protect from light, sealed
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Folinic acid calcium salt, Leucovorin supplier, Antifolate, inhibitors

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