Folinic acid is an adjuvant used in cancer chemotherapy involving the compound methotrexate. Folinic acid serves as a cofactor and participates in one-carbon-transfer reactions. It helps in improving wound healing in rats. Folinic acid calcium salt has been used in the preparation of topical 1% and 2.5% folinic acid creams for use in wound healing studies. It has also been used as a component in the chemically defined-Chinese hamster ovary medium (CD-CHO) to culture CHO DUKX B11.
PLoS One. 2020 May 18;15(5):e0231588.
Patient-derived Oral Mucosa Organoids as an in Vitro Model for Methotrexate Induced Toxicity in Pediatric Acute Lymphoblastic Leukemia
Folinic acid calcium salt purchased from AbMole
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Water ≥ 50 mg/mL|
|Storage||4°C, dry, protect from light, sealed|
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